Derek J Huffman

Learn More
Contemporary theories of the medial temporal lobe (MTL) suggest that there are functional differences between the MTL cortex and the hippocampus. High-resolution functional magnetic resonance imaging and multivariate pattern analysis were utilized to study whether MTL subregions could classify categories of images, with the hypothesis that the hippocampus(More)
Accurate memory for discrete events is thought to rely on pattern separation to orthogonalize the representations of similar events. Previously, we reported that a behavioral index of pattern separation was correlated with activity in the hippocampus (dentate gyrus, CA3) and with integrity of the perforant path, which provides input to the hippocampus. If(More)
A clinical study was conducted to compare the amount and rate of movement and the tipping of canines retracted on 0.016 inch and 0.020 inch round wire with a continuous force of 200 grams and medium-width 0.022 inch by 0.028 inch nonangulated Siamese brackets. On one side canines were retracted on 0.016 inch wire and on the other side of the same arches, on(More)
Since the earliest attempts to characterize the "receptive fields" of neurons, a central aim of many neuroscience experiments is to elucidate the information that is represented in various regions of the brain. Recent studies suggest that, in the service of memory, information is represented in the medial temporal lobe in a conjunctive or associative form(More)
Previous studies from our lab have indicated that healthy older adults are impaired in their ability to mnemonically discriminate between previously viewed objects and similar lure objects in the Mnemonic Similarity Task (MST). These studies have used either old/similar/new or old/new test formats. The forced-choice test format (e.g., "Did you see object A(More)
  • 1