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A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
It's a Knockout The malaria parasite is one of the most important pathogens of humans. Increasing drug-resistance is an imminent public health disaster, and we urgently need to find new drugs. TheExpand
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Citral Sensing by TRANSient Receptor Potential Channels in Dorsal Root Ganglion Neurons
Transient receptor potential (TRP) ion channels mediate key aspects of taste, smell, pain, temperature sensation, and pheromone detection. To deepen our understanding of TRP channel physiology, weExpand
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Diagnosis pathway for patients with amyotrophic lateral sclerosis: retrospective analysis of the US Medicare longitudinal claims database
BackgroundInitial symptoms of amyotrophic lateral sclerosis (ALS) are often subtle and can delay diagnosis. This exploratory analysis was conducted to better characterize the pre-diagnosis pathwayExpand
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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Trypanothione reductase (TR), an enzyme that buffers oxidative stress in trypanosomatid parasites, was screened against commercial libraries containing approximately 134,500 compounds. AfterExpand
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Correction: Citral Sensing by Transient Receptor Potential Channels in Dorsal Root Ganglion Neurons
There was an error in the published title of this manuscript. The correct title is: "Citral Sensing by Transient Receptor Potential Channels in Dorsal Root Ganglion Neurons."
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Current and Future Disease Progression of the Chronic HCV Population in the United States
Chronic hepatitis C virus (HCV) infection can lead to advanced liver disease (AdvLD), including cirrhosis, decompensated cirrhosis, and liver cancer. The aim of this study was to determine recentExpand
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Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.
Two sets of diaminopyrimidines, totalling 45 compounds, were synthesized and assayed against Plasmodium falciparum. The SAR was relatively shallow, with only the presence of aExpand
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Antiplasmodial activity of piperazine sulfonamides.
A high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum. Both screening positives had three structural features with potentialExpand
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Reduction in hospital costs and resource consumption associated with the use of advanced topical hemostats during inpatient procedures
Abstract Objective: The use of hemostatic agents has increased over time for all surgical procedures. The purpose of this study was to evaluate the newer topical absorbable hemostat products SurgicelExpand
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Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Artemisinin-derived compounds play an integral role in current malaria chemotherapy. Given the virtual certainty of emerging resistance, we have investigated spiro-1,2-dioxolanes as an alternativeExpand
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