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A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation. Heart regeneration: Small cues from developmentExpand
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Plasticity of Hopx+ Type I alveolar cells to regenerate Type II cells in the lung
The plasticity of differentiated cells in adult tissues undergoing repair is an area of intense research. Pulmonary alveolar Type II cells produce surfactant and function as progenitors in the adult,Expand
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Effects of flow shear stress and mass transport on the construction of a large-scale tissue-engineered bone in a perfusion bioreactor.
Currently, a tissue-engineered bone is usually constructed using a perfusion bioreactor in vitro. In the perfusion culture, fluid flow can exert shear stress on the cells seeded on scaffold,Expand
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Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
BACKGROUND Genetic or nutritional disturbances in folate metabolism may affect embryonic development because of the critical role of folate in nucleotide synthesis and methylation reactions. TheExpand
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Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury
Taste buds are composed of a variety of taste receptor cell types that develop from tongue epithelium and are regularly replenished under normal homeostatic conditions as well as after injury. TheExpand
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Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts
Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, the identity of a markerExpand
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Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
BACKGROUND The etiology of neural tube defects (NTDs) is multifactorial, with environmental and genetic determinants. Folate supplementation prevents the majority of NTDs, and a polymorphism inExpand
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Hopx distinguishes hippocampal from lateral ventricle neural stem cells.
In the adult dentate gyrus (DG) and in the proliferative zone lining the lateral ventricle (LV-PZ), radial glia-like (RGL) cells are neural stem cells (NSCs) that generate granule neurons. A numberExpand
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Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis
Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family, plays an important role in regulating the actin cytoskeleton via mediation of linear actinExpand
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Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inheritable myocardial disorder associated with fibrofatty replacement of myocardium and ventricular arrhythmia. A subset of ARVC isExpand
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