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Carbohydrate microarrays for the recognition of cross-reactive molecular markers of microbes and host cells
- Denong Wang, Shaoyi Liu, Brian J. Trummer, Chao Deng, Aili Wang
- BiologyNature Biotechnology
- 1 March 2002
The development of a carbohydrate-based microarray to extend the scope of biomedical research on carbohydrate-mediated molecular recognition and anti-infection responses is described and the potential of carbohydrate microarrays is demonstrated by the discovery of previously undescribed cellular markers, Dex-Ids.
PRDM1/Blimp‐1 is expressed in human B‐lymphocytes committed to the plasma cell lineage
- G. Cattoretti, C. Angelin-Duclos, R. Shaknovich, Huiping Zhou, Denong Wang, B. Alobeid
- Biology, MedicineThe Journal of pathology
- 1 May 2005
In conclusion, PRDM1 staining is a reliable and informative assay to define plasma cell commitment and differentiation in human normal and neoplastic B‐cell lineages.
Normalization of cDNA microarray data by using neural networks
- Chao Deng, Peisen Zhang, Aili Wang, Brian J. Trummer, Denong Wang
- EngineeringProceedings of the International Joint…
- 7 August 2002
A nonlinear method for the normalization, i.e. neural network normalization (N3) approach, of cDNA microarray experiments in the community of bioinformatics is proposed, which can obtain much better normalization performance of c DNA microarray data than current existing approaches.
Protein synthesis at synapse versus cell body: enhanced but transient expression of long-term facilitation at isolated synapses.
After removal of the SN cell body, isolated SN synapses of Aplysia in culture express protein-synthesis dependent long-term facilitation (LTF) produced by 5-HT that decays rapidly.
The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins.
Programmed cell removal by calreticulin in tissue homeostasis and cancer
The authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on cancer cells, determining in both cases clearance by PrCR.
Enhanced immune recognition of cryptic glycan markers in human tumors.
Vaccination with FasL-expressing tumors enables the immune system to break tolerance to self-antigens, allowing identification of novel TACAs that can form the basis of future humoral anticancer therapy.
A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies.
A water-soluble glycopeptide, fractionated and purified from the aqueous extract of the fruiting bodies of Ganoderma lucidum, showed lower DPPH radical-scavenging activity but possessed higher superoxide radical-quenching potency, suggesting that it could be presented as a possible new source of natural antioxidants.
Structural characterization and DPPH radical scavenging activity of an arabinoglucogalactan from Panax notoginseng root.
The structure of an antiradical arabinoglucogalactan from Panax notoginseng roots was determined and exhibited high scavenging activity against DPPH free radicals, suggesting that this arabinosaccharide is a potential antirADical.
Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry*
Construction of a “glucome” microarray is described, the first sequence-defined glycome-scale microarray, using a "designer” approach from targeted ligand-bearing glucans in conjunction with a novel high-sensitivity mass spectrometric sequencing method, as a screening tool to assign glucan recognition motifs.