Dennis Worthington

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The ability of amniotic membrane, obtained with 3 h of delivery of 28 infants, to interconvert 3H-cortisol and 14-C-cortisone has been examined. The conversion of cortisone to cortisol increases as a function of gestational age, being first seen at 29.5 weeks and reaching values of 50--55% at term (n = 28, r = 0.615, P less than 0.01). Furthermore, a net(More)
BACKGROUND Mirror syndrome, a rare condition characterized by maternal anasarca in a pregnancy complicated by fetal hydrops, may have a devastating fetal outcome and significant maternal morbidity. CASE We report a case of mirror syndrome caused by parvovirus B19 infection, which resolved spontaneously with good fetal and maternal outcome. CONCLUSION(More)
Fetal heart rate profiles for periods up to 12 hours prior to delivery have been reviewed in 515 patients with a fetus at risk. Mechanisms other than fetal asphyxia will cause fetal heart rate decelerations, and fetal asphyxia may in some instances develop in the absence of total or late decelerations. However, an increasing incidence of total decelerations(More)
To evaluate its clinical value, the half-life of caffeine (1,3,7-trimethylxanthine) in saliva (SCT) after 3 mg/kg-1 oral caffeine was measured in 53 children with chronic liver disease (mean age, 4.41 years) and 48 control children (mean age, 6.26 years) in five samples over 24 h and compared with parameters of liver function and outcome. Sensitivity was(More)
OBJECTIVE To assess the benefit of nebulised amiloride added to the standard inpatient treatment of a respiratory exacerbation in cystic fibrosis. DESIGN Prospective, randomised, double blind, placebo controlled trial. SUBJECTS 27 cystic fibrosis patients (mean age 12.8 years). SETTING Two hospitals in Leeds, UK. RESULTS Both forced expiratory(More)
The clinical characteristics of 124 pregnancies complicated by intrapartum fetal asphyxia have been reviewed. The evidence of fetal asphyxia tends to appear earlier in patients with maternal medical and obstetric complications than in those with labor complications. Evidence of clinical fetal distress was present in 36 per cent and was not related to the(More)
The number of uterine caruncles was reduced by electrocautery in nonpregnancy sheep. Subsequent pregnancies were studied as chronic fetal sheep preparations between 110 days' gestation and term; findings were compared with those for control chronic fetal sheep preparations at a similar gestational age. As a result of decreased weight and reduced number of(More)
Six hundred high-risk monitored obstetric patients were reviewed for evidence of fetal asphyxia at delivery. The over-all incidence was 20 per cent, i.e., 8 times the incidence in a normal obstetric population. Highly significant indicators of risk for asphyxia were severe toxemia (79 per cent), prematurity with further medical or obstetric complications(More)
In a group of 81 prematurely delivered infants the amniotic fluid lecithin/sphingomyelin ratio was related to functional fetal lung maturity. Intrapartum fetal asphyxia occurred in 33% of the group. An association between fetal asphyxia and the development of respiratory distress syndrome (RDS) in the infant was observed. When pulmonary maturity was(More)
Chronic maternal administration of diazepam resulted in a modification of fetal respiratory-like activity (FRLA) in the sheep. An over-all increase in this activity occurred. This increase was probably due to a rebound effect following periods of acute suppression with each administration of diazepam. Loss of central control in the regulation of FRLA was(More)