Dennis Trede

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Inline digital holograms are classically reconstructed using linear operators to model diffraction. It has long been recognized that such reconstruction operators do not invert the hologram formation operator. Classical linear reconstructions yield images with artifacts such as distortions near the field-of-view boundaries or twin images. When objects(More)
3D imaging has a significant impact on many challenges in life sciences, because biology is a 3-dimensional phenomenon. Current 3D imaging-technologies (various types MRI, PET, SPECT) are labeled, i.e. they trace the localization of a specific compound in the body. In contrast, 3D MALDI mass spectrometry-imaging (MALDI-MSI) is a label-free method imaging(More)
In the last decade, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), also called as MALDI-imaging, has proven its potential in proteomics and was successfully applied to various types of biomedical problems, in particular to histopathological label-free analysis of tissue sections. In histopathology, MALDI-imaging is used(More)
BACKGROUND Three-dimensional (3D) imaging mass spectrometry (MS) is an analytical chemistry technique for the 3D molecular analysis of a tissue specimen, entire organ, or microbial colonies on an agar plate. 3D-imaging MS has unique advantages over existing 3D imaging techniques, offers novel perspectives for understanding the spatial organization of(More)
Imaging Mass Spectrometry (imaging MS) is a technology for spatial analytics that has experienced a significant uptake in recent years. A diverse set of applications and analytical platforms have been reported across the field of imaging MS for imaging molecules from many different chemical classes; but there is little quantified information about the(More)
Image segmentation aims at partitioning an image into multiple segments. The application of this procedure produces a label map (also referred to as segmentation map) that classifies the pixels of the original image. In contrast to "natural" images, label maps are nominal-scale images, typically represented as integer-valued images. Nominal-scaled label(More)
1 Einführung Sowohl die Entwicklung neuer Wirkstoffe in der Medikamentenforschung als auch die Suche nach krankheitsspezifischen Biomarkern in der diagnostischen Medizin sowie eine individualisierte Therapieplanung erfordern eine detaillierte Kenntnis über den Metabolismus des untersuchten Organismus und dessen pathologische Veränderungen [AD09]. Da die(More)
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