Dennis Thiele

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Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects. Malnourished children, the elderly, and pregnant or lactating females may be susceptible for Cu deficiency. Cu status and exposure in the population can currently not be easily measured, as(More)
RNA Recognition and Regulation of the AU-rich RNA Binding Proteins: HuR, TTP and BRF1 by Matthew Burk Friedersdorf Department of Pharmacology and Molecular Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Jack Keene, Supervisor ___________________________ Matthais Gromeier ___________________________ Jeffrey(More)
Ribonomic and Mechanistic Analysis of the Human Pum1 RNA Binding Protein by Adam Remy Morris University Program in Genetics and Genomics Duke University Date:_______________________ Approved: ___________________________ Jack Keene, Chair ___________________________ David Pickup ___________________________ Jen-Tsan Chi ___________________________ Uwe Ohler(More)
The clinical use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) has proven to be a strong diagnostic tool in the field of neurology. The reliability of these methods to confirm clinical diagnoses has guided preclinical research to utilize these techniques for the characterization of animal disease models. Previously, we(More)
Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum by Sonja Nicole Brun Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Robert Wechsler-Reya, Co-Supervisor ___________________________ Donald McDonnell, Co-Supervisor ___________________________ Dennis(More)
Targeting Inducible Heat Shock Protein 70 in Cancer and Dengue Virus Pathogenesis with a Novel Small Molecule Inhibitor by Matthew Keller Howe Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Timothy Haystead, Supervisor ___________________________ Stacy Horner(More)
eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation by Christian Goetz Department of Pharmacology and Cancer Biology Duke University Date:_______________________ Approved: ___________________________ Matthias Gromeier, Supervisor ___________________________ Dennis Thiele ___________________________ Christopher Nicchittaa(More)
Hepatocellular carcinoma (HCC) represents the second leading cause of cancer-related deaths and is reported to be resistant to chemotherapy caused by tumor-initiating cells. These tumor-initiating cells express stem cell markers. An accumulation of tumor-initiating cells can be found in 2% to 50% of all HCC and is correlated with a poor prognosis.(More)
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