Dennis P. McCarthy

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OBJECTIVE We conducted a literature review of assessment tools predicting driving performance for people with traumatic brain injury (TBI). METHOD Data sources were Web of Science, EBSCOhost, PubMed, and recently published literature from experts and team members not yet catalogued in the databases. We used the American Academy of Neurology's(More)
PURPOSE To determine the correlations of the Useful Field of View (UFOV), compared to other clinical tests of Parkinson's disease (PD); vision; and cognition with measures of on-road driving assessments and to quantify the UFOV's ability to indicate passing/failing an on-road test in people with PD. METHODS Nineteen randomly selected people with(More)
PROBLEM As the number of older drivers grows, it is increasingly important to accurately identify at-risk drivers. This study tested clinical assessments predictive of real-time driving performance. METHOD Selected assessment tools considered important in the identification of at-risk older drivers represented the domains of vision, cognition, motor(More)
On December 1 and 2, 2003, 63 international experts on older driver issues met to examine three critical issues related to the safe mobility of older drivers. Conference participants addressed standards and protocols for screening and evaluating the skills of older drivers. For drivers judged to lack the necessary skills to drive safely, participants(More)
We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven drugs had solubility <10 μM. Using these data, we established a solubility criterion to support CNS discovery. The implication of poor solubility with potential safety concerns and undesirable side(More)
There has been a long-recognised association between extent of driving and crash involvement: the lower the annual mileage driven, the higher the per-distance crash rate. Because older drivers generally drive less distance per year than others, this association has been used to explain much of their apparent over-involvement in crashes. Several studies from(More)
PURPOSE The Federal Highway Administration (FHWA) proposed guidelines for highway design to increase the safe driving ability of older drivers; however, little empirical evidence exists to support the effectiveness of these guidelines. The purpose of this study was to investigate the effects of implementing these guidelines (in 4 pairs of intersections) on(More)
OBJECTIVE To test the effectiveness of the FHWA guidelines for intersection design. METHODS In an experimental design we used kinematics measures from an instrumented vehicle and behavioral (error) data collected during on-road evaluations to quantify the effects of improved versus unimproved intersections (turn phase) and to determine if these(More)
Twelve healthy male subjects were required to make speeded judgements concerning the orientation of visual stimuli while breathing air at reduced partial pressure in a hypobaric chamber at altitudes of 7000 and 12,000 ft. A control condition was also conducted at sea level, and subjects received practice on the task at sea level prior to the commencement of(More)