Dennis L. Huczek

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Poor oral biovailability of three experimental compounds, I ~ III, observed in animals has been attributed to the low intrinsic solubility. To enhance their GI absorption, we attempted to increase the solubility of these compounds with hydroxypropyl β-cyclodextrin (HPB)4 and γ-cyclodextrin (HPG). Compound I showed an increase in solubility over 1,000-fold(More)
The effects of a selective bradykinin 1 receptor antagonist, compound A, were evaluated in a canine model of acute inflammatory model of arthritis. Despite detection of the B1 receptor in canine type B synoviocytes using a fluorescent ligand, oral administration of compound A (9 and 27 mg/kg) did not improve weight bearing of dogs injected intra-articularly(More)
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