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The paraventricular nucleus of the rat hypothalamus has been shown to project to the medulla and spinal cord. The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown. A major difficulty in resolving this problem in previous immunocytochemical studies was the lack of a specific antiserum to(More)
Immunoperoxidase technique and light microscopy were used to investigate the distribution of vasoactive intestinal polypeptide (VIP) in mouse and rat brain. Both 50 micrometers unmounted cryostat and 6 micrometers deparaffinized sections were studied in coronal or sagittal plane. At least 4 different major VIP systems were found: (1) an intracerebral(More)
We find strong evidence of a stable " money demand " relationship for MZM and M2M through the 1990s. Though the M2 relation breaks down somewhere around 1990, evidence has been accumulating that the disturbance is well characterized as a permanent upward shift in M2 velocity, which began around 1990 and was largely over by 1994. Taken together, our results(More)
Neurophysin and vasopressin-containing terminals in the zona externa of the median eminence (ZE) show a large increase in immunoreactive peptide following adrenalectomy which can be prevented by dexamethazone replacement therapy. The present study was undertaken to determine the effectiveness of a glucocorticoid (corticosterone; CS) and a mineralocorticoid(More)
The distribution of afferents to the paraventricular nucleus of the hypothalamus (PVN) was studied following iontophoresis of horseradish peroxidase (HRP) into the nucleus. This report describes the descending connections to this structure. The PVN receives a substantial input from limbic system structures, especially from the lateral septal nucleus and the(More)
1. By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior pituitary gland in the rat. 2. Like vasopressin and its neurophysin, but not oxytocin, ANG II was also found(More)
This study was designed to determine the relative contribution of vasopressin-secreting nerve terminals in the median eminence compared to those in posterior pituitary to the high concentrations of the hormone in hypophysial portal blood. Vasopressin was measured by radioimmunoassay in plasma obtained by microcannulation of individual long portal veins of 8(More)