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  • Dennis J Selkoe
  • Medicine
  • Cold Spring Harbor perspectives in biology
  • 2011
  • Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of theExpand
  • Dennis J Selkoe
  • Biology, Medicine
  • Physiological reviews
  • 2001 (First Publication: 1 April 2001)
  • Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and associationExpand
  • Ganesh M. Shankar, Brenda L Bloodgood, Matthew Townsend, Dominic M Walsh, Dennis J Selkoe, Bernardo L. Sabatini
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2007 (First Publication: 14 March 2007)
  • Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment.Expand
  • Donalyn Scheuner, Chris Eckman, +18 authors Steven G. Younkin
  • Medicine
  • Nature medicine
  • 1996
  • To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellularExpand