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Cortisol and epinephrine control opposing circadian rhythms in T cell subsets.

• Stoyan Dimitrov, Christian Benedict, Dennis Heutling, Jürgen Westermann, Jan Born, Tanja Lange
• Blood
• 2009

Pronounced circadian rhythms in numbers of circulating T cells reflect a systemic control of adaptive immunity whose mechanisms are obscure. Here, we show that circadian variations in T cell… (More)

Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.

• Dennis Heutling, Hasmik Schulz, +9 authors Hendrik Lehnert
• The Journal of clinical endocrinology and…
• 2008

CONTEXT Insulin resistance plays a significant role in the pathogenesis of the polycystic ovary syndrome (PCOS) and represents a link to the unfavorable cardiovascular risk profile frequently found… (More)

Insulin and Metformin Regulate Circulating and Adipose Tissue Chemerin

• Bee Kim Tan, Jing Chen, +7 authors Harpal Randeva
• Diabetes
• 2009

OBJECTIVE To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS Real-time… (More)

Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.

• Bee Kim Tan, Dennis Heutling, +6 authors Harpal Randeva
• Diabetes
• 2008

OBJECTIVE Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Vaspin (visceral adipose tissue-derived serine protease inhibitor) levels increase with hyperinsulinemia… (More)

Lipoprotein apheresis in patients with maximally tolerated lipid-lowering therapy, lipoprotein(a)-hyperlipoproteinemia, and progressive cardiovascular disease: prospective observational multicenter…

• Josef Leebmann, Eberhard Roeseler, +8 authors Reinhard Klingel
• Circulation
• 2013

BACKGROUND Lipoprotein(a) (Lp(a)) hyperlipoproteinemia is a major risk factor for cardiovascular disease, which is not affected by treatment of other cardiovascular risk factors. This study sought to… (More)

Sympathetic function in human carriers of melanocortin-4 receptor gene mutations.

• Friedhelm Sayk, Dennis Heutling, +6 authors Hendrik Lehnert
• The Journal of clinical endocrinology and…
• 2010

CONTEXT Melanocortinergic pathways clearly appear to be involved in obesity-associated sympathetic overactivity and its hemodynamic and thermoregulatory consequences. Individuals with dysfunctional… (More)

Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

• Bee Kim Tan, Raghu Adya, +5 authors Harpal Randeva
• Cardiovascular research
• 2009

AIMS Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR), obesity, and cardiovascular complications. Thrombospondin-1 (TSP-1) is a novel antiangiogenic adipokine highly… (More)

Effects of selective slow-wave sleep deprivation on nocturnal blood pressure dipping and daytime blood pressure regulation.

• Friedhelm Sayk, Christina Teckentrup, +4 authors Christoph Dodt
• American journal of physiology. Regulatory…
• 2010

Nocturnal blood pressure (BP) decline or "dipping" is an active, central, nervously governed process, which is important for BP regulation during daytime. It is, however, not known whether the sleep… (More)

[Polycystic ovary syndrome. Prototype of a cardio-metabolic syndrome].

• Dennis Heutling, H. Schulz, Harpal Randeva, Christoph Dodt, Hendrik Lehnert
• Der Internist
• 2007

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women in the reproductive age and is a major cause of anovulation, hyperandrogenism and infertility. Since obesity and… (More)

Das polyzystische Ovarsyndrom

• Dennis Heutling, H. Schulz, Harpal Randeva, Christoph Dodt, Prof. Dr. Dr. H. Lehnert
• Der Internist
• 2006

Das polyzystische Ovarsyndrom (PCOS) ist eine häufige endokrine Erkrankung und betrifft Frauen im gebärfähigen Alter. Das klinische Bild ist von Zyklusstörungen, Infertilität und Hyperandrogenismus… (More)

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