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I nformation security problems cost millions of dollars for US companies and billions for the overall US economy, according to a joint survey by the Computer Security Institute and the US Federal Bureau of Investigation Nowadays, the question is not whether organizations need more security, but how much to spend for added security.And yet investing in IT(More)
The purpose of this report was to characterize the dynamics of the gene expression cascades induced by an IFN-␤-1a treatment regimen in multiple sclerosis patients and to examine the molecular mechanisms potentially capable of causing heterogeneity in response to therapy. In this open-label pharmacodynamic study design, peripheral blood was obtained from(More)
Since there is limited information in the literature, the purpose of this study was to investigate clinical signs, morphology, and temporal progression of lesions from Days 3 to 168 in a kainic acid (KA)-induced Fischer-344 (F-344) rat model of mesial temporal lobe epilepsy (MTLE). Following a single KA subcutaneous dose of 9 mg/kg to young adult male rats,(More)
For many pathologists, neuropathology is intimidating. Practical approaches for nervous tissue histologic evaluations to meet both routine and advanced study designs can lead to rewarding neuropathology efforts. Cost-effective, high-quality histologic evaluations can occur if animals are exsanguinated quickly, brains removed carefully to maintain structural(More)
Lafora bodies (polyglucosan deposits) were identified in the brain of a young adult cat with neurologic signs characterized by intermittent but progressively worsening head and body tremors. The cerebellar cortex was the most severely affected area of brain, and the deposits were identified within Purkinje cell bodies and processes and throughout the(More)
PURPOSE To investigate the effects of interferon-beta-1a (IFN-beta-1a) on the trafficking of cell populations in peripheral blood cells of multiple sclerosis (MS) patients. METHODS In this open-label pharmacodynamic study, peripheral blood was obtained from 10 relapsing-remitting (RR) MS patients just prior to and at 1, 2, 4, 8, 24, 48, 120, and 168 h(More)
ii ABSTRACT The California Forest Practice Rules (FPRs) (Title 14, California Code of Regulations) are designed in large part to protect water quality and aquatic habitat in forested watersheds during and after silviculture activities (Figure 1). The critical questions then become: 1) At what rate are the water quality related FPRs being properly(More)
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