Dennis H. Lau

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on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia, and Vasovagal Syncope Robert S. Sheldon, MD, PhD, FRCPC, FHRS (Chair), Blair P. Grubb II, MD, FACC (Chair), Brian Olshansky, MD, FHRS, FACC, FAHA, CCDS, Win-Kuang Shen, MD, FHRS, FAHA, FACC, Hugh Calkins, MD, FHRS, CCDS, Michele Brignole, MD, FESC, Satish R.(More)
BACKGROUND Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes. OBJECTIVE The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ablation. METHODS A systematic(More)
Atrial fibrillation (AF) has been established as an independent predictor of long-term mortality after acute myocardial infarction. However, this is less well defined across the whole spectrum of acute coronary syndromes (ACSs). The Acute Coronary Syndrome Prospective Audit is a prospective multicenter registry with 12-month outcome data for 3,393 patients(More)
OBJECTIVES The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). BACKGROUND Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. METHODS One hundred ten(More)
BACKGROUND There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described. OBJECTIVE To determine whether patients with OSA have an abnormal atrial substrate. METHODS Forty patients undergoing ablation of paroxysmal AF and in sinus rhythm (20 with OSA(More)
BACKGROUND In the past decade, catheter ablation has become an established therapy for symptomatic atrial fibrillation (AF). Until very recently, few data have been available to guide the clinical community on the outcomes of AF ablation at ≥3 years of follow-up. We aimed to systematically review the medical literature to evaluate the long-term outcomes of(More)
Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not only linked to the development of risk factors for atherosclerotic vascular disease but also has a strong association with ventricular hypertrophy, heart failure, atrial fibrillation, and stroke. Recent experimental and clinical studies have demonstrated that obesity is(More)
BACKGROUND It has been suggested that omega-3 polyunsaturated fatty acids (n-3 PUFAs) may prevent the development of atrial fibrillation (AF). OBJECTIVE The purpose of this study was to evaluate the impact of these agents on development of the AF substrate in heart failure (HF). METHODS In this study, HF was induced by intracoronary doxorubicin(More)
BACKGROUND Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. OBJECTIVE To examine the effect of progressive weight gain on the substrate for AF. METHODS Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for(More)
BACKGROUND Obesity and atrial fibrillation (AF) frequently coexist. Weight loss reduces the burden of AF, but whether this is sustained, has a dose effect, or is influenced by weight fluctuation is unknown. OBJECTIVES This study sought to evaluate the long-term impact of weight loss and weight fluctuation on rhythm control in obese individuals with AF. (More)