Dennis F. Kohn

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Hydrocephalic neonates were observed in a small breeding colony of rats. Normal rats from this colony were obtained and brother-sister mated for seven generations. The overall prevalence of hydrocephalics was approximately 23%; however, in one subline, the prevalence approached 50%. Breeding data suggested the trait to be polygenic. Hydrocephalics could be(More)
In the interval between the publication of the seventh and eighth editions of the Guide for the Care and Use of Laboratory Animals (Guide), much has changed with regard to the regulation and funding of highly pathogenic biologic agents and toxins (Select Agents). Funding of research involving highly pathogenic agents has increased dramatically during this(More)
The ACLAM Analgesia Task Force was appointed by ACLAM President Diane Gaertner in 2003. The charge to the Task Force was to develop guidelines that could be used by veterinarians, scientists and IACUCs in helping to provide appropriate assessment and management of pain in rodents, with the understanding that ultimately the clinical veterinarian on site at(More)
Mycoplasma pulmonis, a pathogen of the respiratory tract in rats, was inoculated intracerebrally into neonate rats and hamsters to determine if it would induce lesions in the ependyma. Hydrocephalus was induced in 116 of 120 rats and in 23 of 28 hamsters. The severity of hydrocephalus was greater in the rats than in the hamsters. Hydrocephalus induction(More)
Oxymorphone was administered epidurally (0.1 mg/kg) or intramuscularly (IM) (0.2 mg/kg) to 16 dogs undergoing thoracotomy, to compare the analgesic effectiveness. Heart rate, respiratory rate, systolic and diastolic blood pressure, and pain score were measured hourly. Arterial blood gases were measured at hour 1. A single dose of oxymorphone injected(More)
Ependymal organ culture was used as a model to study the effect of Mycoplasma pulmonis on the ciliated ependyma of the rat. Reduced ciliary activity or ciliostasis occurred 48 to 72 h after infection. Scanning electron microscopy showed that numerous organisms were associated with the cytoplasmic membrane of host cells beginning at 24 h, and transmission(More)
Decreased fertility was observed in a breeding colony of C57BL/6J mice. On examination, a dorsoventral vaginal septum was detected in many females. This defect was identified in 1976, with incidence of 4.0% in this strain. Our objective was to determine whether incidence of this condition has increased and whether this defect was associated with the(More)