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Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases
Summary Holliday junctions (HJs) are X-shaped DNA structures that arise during homologous recombination, which must be removed to enable chromosome segregation. The SLX1 and MUS81-EME1 nucleases canExpand
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Noncanonical mismatch repair as a source of genomic instability in human cells.
Mismatch repair (MMR) is a key antimutagenic process that increases the fidelity of DNA replication and recombination. Yet genetic experiments showed that MMR is required for antibody maturation, aExpand
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Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres
Summary SLX4, a scaffold for structure-specific DNA repair nucleases, is important for several types of DNA repair. Many repair proteins bind to sites of DNA damage, resulting in subnuclear “foci,”Expand
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Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation
In eukaryotic mismatch repair (MMR), degradation of the error-containing strand initiates at nicks or gaps that can be up to a kilobase away from the mispair. These discontinuities may be the ends ofExpand
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Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells.
(Molecular Cell 47, 669–680; September 14, 2012) As a result of an author oversight in the originally published version of this article, a key funding source for Javier Peña-Diaz, MarielaExpand
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The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo
The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNAExpand
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Proteome profiling suggests a pro‐inflammatory role for plasma cells through release of high‐mobility group box 1 protein
The final step of B‐cell maturation is to differentiate into plasma cells, a process that is accompanied by gross changes in subcellular organization to enable antibody secretion. To betterExpand
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Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia
ABSTRACT Defects in SLX4, a scaffold for DNA repair nucleases, result in Fanconi anemia (FA), due to the defective repair of inter-strand DNA crosslinks (ICLs). Some FA patients have an SLX4 deletionExpand
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The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination.
Spontaneous hydrolytic deamination of DNA bases represents a considerable mutagenic threat to all organisms, particularly those living in extreme habitats. Cytosine is readily deaminated to uracil,Expand
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Chromosome Missegregation Associated with RUVBL1 Deficiency
RUVBL1 (RuvB-like1) and RUVBL2 (RuvB-like 2) are integral components of multisubunit protein complexes involved in processes ranging from cellular metabolism, transcription and chromatin remodelingExpand
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