Denise Thompson

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The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of amyloid deposits, and contributes to the pathogenesis of amyloidosis. In order to intervene in this process we have developed a drug, R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid, that is a competitive inhibitor of SAP binding to(More)
BACKGROUND Objectively measured circulating biomarkers of prognosis complementing existing clinicopathological models are needed in renal cell carcinoma (RCC). METHODS Blood samples collected from 216 RCC patients in Leeds before nephrectomy (median follow-up 7 years) were analysed for C-reactive protein (CRP), osteopontin (OPN) and carbonic anhydrase IX(More)
BACKGROUND Validated objective biomarkers are needed for patients with renal cell carcinoma (RCC) to guide patient management and define high-risk populations for follow-up or for therapeutic purposes. METHODS Patients undergoing nephrectomy for RCC (n=286 all stages, 84% with conventional clear cell type) were included with a median duration follow-up of(More)
BACKGROUND In renal cell carcinoma (RCC), the discovery of biomarkers for clinical use is a priority. This study aimed to identify and validate diagnostic and prognostic serum markers using proteomic profiling. METHODS Pre-operative sera from 119 patients with clear cell RCC and 69 healthy controls was analysed by surface-enhanced laser(More)
BACKGROUND No circulating markers are routinely used for renal cancer. The objective of this pilot study was to investigate whether conditioned media (CM) from renal cancer cell lines contains potential biomarkers that, when measured in clinical fluids, have diagnostic or prognostic utility. METHODS Comparative 2D PAGE profiling of CM from renal cell(More)
Introduction levels, and one of their strengths is that they permit a more global, integrated view of the National (1) and European (2) legislation human brain. requires the replacement, reduction and refine­ However, replacing animal experiments ment of animal experiments wherever feasible, requires more than technology: it also needs placing a(More)
Acknowledgements The authors thank the members of the research team and the HASI Evaluation Reference Group for their advice and comments on the Evaluation Plan. Executive Summary NSW Health and Housing NSW have commissioned a research team led by the Social Policy Research Centre (SPRC) to conduct an evaluation of the Mental Health, Housing and(More)