Denise O. Garrett

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OBJECTIVE To determine the prevalence of intensive care unit-acquired infections, a major cause of morbidity in pediatric intensive care unit (PICU) patients. METHODS Pediatric Prevention Network hospitals (n = 31) participated in a point-prevalence survey on August 4, 1999. Data collected for all PICU inpatients included demographics, infections,(More)
SETTING Four general Brazilian hospitals. OBJECTIVE To assess the occupational risk of Mycobacterium tuberculosis (TB) in participating hospitals. DESIGN In phase one of this longitudinal study, a cross-sectional survey documented baseline tuberculin skin test (TST) positivity rates. In phase two, TST conversion rates were evaluated in participants with(More)
BACKGROUND The human immunodeficiency virus (HIV) fuels tuberculosis (TB) epidemics. In controlled clinical trials, antiretroviral therapy (ART) reduces TB incidence in HIV-infected patients. In this study we determine if, under programmatic conditions, Brazil's policy of universal ART access has impacted TB incidence among HIV-infected patients. METHODS(More)
RATIONALE IFN-γ release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for diagnosis of latent tuberculosis infection. Limited data suggest IGRAs may not perform well for serial testing of healthcare workers (HCWs). OBJECTIVES Determine the performance characteristics of IGRAs versus TST for serial testing of HCWs. METHODS A(More)
OBJECTIVES Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. STUDY DESIGN We conducted a point prevalence survey(More)
BACKGROUND Centers for Disease Control and Prevention requirements for pre-immigration tuberculosis (TB) screening of children 2- to 14-years old permit a tuberculin skin test (TST) or an interferon-gamma release assay (IGRA). Few data are available on the performance of IGRAs versus TSTs in foreign-born children. METHODS We compared the performance of(More)
BACKGROUND Coagulase-negative staphylococci (CNS) are the major cause of nosocomial bloodstream infection. Emergence of vancomycin resistance among CNS is a serious public health concern, because CNS usually are multidrug-resistant, and glycopeptide antibiotics, among which only vancomycin is available in the United States, are the only remaining effective(More)
OBJECTIVE The number of immunocompromised patients in hospitals has increased, resulting in a concomitant increase in the number of Aspergillus spp infections, with an exceedingly high death rate. From January 1995 through June 1996, 7 patients acquired invasive aspergillosis at a Maryland hospital (Hospital A). No cases had been detected in 1994. METHODS(More)