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Among the members of the Bcl-2 family, the multidomain proteins Bax and Bak are crucial for the activation of mitochondria. However, it is still unclear whether they act in a unique and distinct manner or whether they exhibit redundant functions. To systematically investigate their activation on a single-cell level, we established MCF-7 cell lines stably(More)
Pifithrin-alpha (PFT-alpha) was shown to specifically block transcriptional activity of the tumor suppressor p53 and was therefore proposed to be useful in preventing the severe side effects often associated with chemo- and radiotherapy. We report here that although PFT-alpha efficiently protected different cell types from DNA damage-induced apoptosis, it(More)
The p90 ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. As they are almost exclusively activated downstream of extracellular signal-regulated kinases 1 and 2 (ERK1/2), therapeutic intervention by RSK inhibition is less likely to produce such severe side effects(More)
Although initially described as a regulator of cell cycle progression, the cyclin-dependent kinase inhibitor p21 is now known to also modulate various other biological processes including transcription, differentiation and apoptosis. These versatile activities of p21 are mainly mediated via direct binding to various transcription factors, pro-apoptotic(More)
Geiger-mode Avalanche Photodiodes (G-APD) bear the potential to significantly improve the sensitivity of Imaging Air Cherenkov Telescopes (IACT). We are currently building the First G-APD Cherenkov Telescope (FACT) by refurbishing an old IACT with a mirror area of 9.5 square meters and construct a new, fine pixelized camera using novel G-APDs. The main goal(More)
The First G-APD Cherenkov Telescope (FACT) is an Imaging Air Cherenkov Telescope located on the Canary Island of La Palma. It is the first of its kind which uses Geiger-mode Avalanche Photo Diodes (G-APDs) as photosensors to detect the Cherenkov radiation emitted from secondary particles in a high-energy gamma-ray air shower. A new analysis chain has been(More)
  • J. Buß∗b, M. L. Ahnen, +15 authors J. Buß
  • 2015
The First G-APD Cherenkov Telescope (FACT) is the first operational telescope of its kind, employing a camera equipped with silicon photon detectors (G-APD aka. SiPM). SiPMs have a high photon detection efficiency (PDE), while being more robust to bright light conditions than the commonly used photo-multiplier tubes. This technology has allowed us to(More)
Within the FACT project, we construct a new type of camera based on Geiger-mode avalanche photodiodes (G-APDs). Compared to photomultipliers, G-APDs are more robust, need a lower operation voltage and have the potential of higher photon-detection efficiency and lower cost, but were never fully tested in the harsh environments of Cherenkov telescopes. The(More)
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