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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*
- Gwendolyn T. Wong, D. Manfra, +10 authors E. Parker
- Journal of Biological Chemistry
- 26 March 2004
Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive approach to the… Expand
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.
Inhibition of gamma-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce the pathogenic beta-amyloid (Abeta) peptides, is an attractive… Expand
Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma
- Tong-Yuan Yang, S. Chen, +8 authors S. Lira
- Biology, Medicine
- The Journal of experimental medicine
- 7 February 2000
Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic agent for KS, an angiogenic tumor composed of endothelial, inflammatory, and… Expand
Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
- L. Feder, D. Stelts, +9 authors T. Kung
- Biology, Medicine
- American journal of respiratory cell and…
- 1 October 1997
Nitric oxide (NO) is an important mediator of inflammatory reactions and may contribute to the lung inflammation in allergic pulmonary diseases. To assess the role of NO in pulmonary inflammation, we… Expand
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
- P. Holst, M. Rosenkilde, +7 authors S. Lira
- Biology, Medicine
- The Journal of clinical investigation
- 15 December 2001
ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in… Expand
Disruption of Neutrophil Migration in a Conditional Transgenic Model: Evidence for CXCR2 Desensitization In Vivo
We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the β-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatment… Expand
IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4(+) T cells. EAE classically presents with a progressive ascending paralysis and is… Expand
IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis1
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and is a… Expand
Regulatory effects of interleukin-4 and interleukin-10 on human neutrophil function ex vivo and on neutrophil influx in a rat model of arthritis.
OBJECTIVE To assess the capacity of interleukin-4 (IL-4) and IL-10 to block polymorphonuclear neutrophil (PMN) activation in an ex vivo human model system, and to confirm their effect on neutrophil… Expand
Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor…
- L. Hyde, N. McHugh, +9 authors G. Higgins
- Medicine, Chemistry
- Journal of Pharmacology and Experimental…
- 1 December 2006
Accumulation of amyloid β-peptide (Aβ) is considered a key step in the etiology of Alzheimer's disease. Aβ is produced by sequential cleavage of the amyloid precursor protein by β- and γ-secretase… Expand