• Publications
  • Influence
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*
Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive approach to theExpand
  • 592
  • 23
  • PDF
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.
Inhibition of gamma-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce the pathogenic beta-amyloid (Abeta) peptides, is an attractiveExpand
  • 283
  • 21
Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma
Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic agent for KS, an angiogenic tumor composed of endothelial, inflammatory, andExpand
  • 410
  • 15
  • PDF
Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
Nitric oxide (NO) is an important mediator of inflammatory reactions and may contribute to the lung inflammation in allergic pulmonary diseases. To assess the role of NO in pulmonary inflammation, weExpand
  • 99
  • 6
  • PDF
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed inExpand
  • 96
  • 6
  • PDF
Disruption of Neutrophil Migration in a Conditional Transgenic Model: Evidence for CXCR2 Desensitization In Vivo
We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the β-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatmentExpand
  • 70
  • 4
IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4(+) T cells. EAE classically presents with a progressive ascending paralysis and isExpand
  • 63
  • 4
IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis1
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and is aExpand
  • 88
  • 3
  • PDF
Regulatory effects of interleukin-4 and interleukin-10 on human neutrophil function ex vivo and on neutrophil influx in a rat model of arthritis.
OBJECTIVE To assess the capacity of interleukin-4 (IL-4) and IL-10 to block polymorphonuclear neutrophil (PMN) activation in an ex vivo human model system, and to confirm their effect on neutrophilExpand
  • 35
  • 3
Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor
Accumulation of amyloid β-peptide (Aβ) is considered a key step in the etiology of Alzheimer's disease. Aβ is produced by sequential cleavage of the amyloid precursor protein by β- and γ-secretaseExpand
  • 61
  • 2