Denise M. McCarthy

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OBJECTIVE Previous uncontrolled studies suggested a therapeutic benefit for treating gastroesophageal reflux disease (GERD) among patients with laryngitis. The present study is the first randomized, placebo-controlled, double-blind study of gastric acid suppression among patients with laryngitis in the United States. METHODS Patients diagnosed with(More)
Thallium-201 myocardial perfusion scintigraphy was performed after exercise, 4 hours after exercise (redistribution) and after a separate rest injection in 87 patients undergoing coronary arteriography. Significant coronary lesions were present in 62 of the patients. Interpretation of the rest and redistribution scintiscans was the same in 69 patients, 45(More)
The stroke-volume ratio determined from the equilibrium gated blood-pool study has been utilized to assess valvular regurgitation, but it is difficult to get reproducible results using generally available equipment. We have developed a new approach utilizing the Fourier amplitude ratio of the left and right ventricles, which is easily implemented and(More)
BACKGROUND Variable clinical outcomes of tibial tuberosity transfer surgery have been reported. HYPOTHESES The biomechanical outcome of surgery is patient-specific; no single procedure produces superior results for all patients. Use of patient-specific computer models can optimize choice of procedure. STUDY DESIGN Computer simulation study using(More)
To evaluate the concept of a predetermined "setpoint" for iron stores, 20 healthy elderly individuals (12 blood donors and 8 nondonors) were studied to examine the effects of changes in iron stores on iron absorption. Oral iron-absorption tests revealed a statistically significant increase (P < 0.001) in iron absorption in donors, 7.4 +/- 3.6% (mean +/- SD)(More)
The effect of the location of right coronary artery (RCA) lesions upon right ventricular ejection fraction (RVEF) during exercise was investigated using first-pass radionuclide angiography. Thirty-seven patients were studied at rest and during upright bicycle exercise: 11 controls (group 1) and 26 patients with significant (>70%) coronary artery stenosis,(More)
It has previously been shown that patients with valvular regurgitation can be identified by the ratio of left and right ventricular amplitude values obtained from first harmonic Fourier analysis of the gated blood pool scan. The present study was designed to validate the accuracy of this technique for quantifying the amount of valvular regurgitation. In a(More)
Management of a partially lacerated digital flexor tendon within zone II remains controversial. To address this issue, we undertook an evaluation of the impact of tenorrhaphy on the gliding function and tensile properties of canine flexor tendons with lacerations involving either 30% or 70% of their cross-sectional area. Assessment of tendon excursion and(More)
The appropriate management of partially lacerated digital flexor tendons in zone 2 is controversial. Tenorrhaphy has been advocated by some on the basis of improving tendon gliding function, whereas others have recommended foregoing tenorrhaphy because of the negative impact of repair on the tensile strength of the tendon. In light of this division, we(More)