Denise L Miles

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By 1995 population aging will decrease the size of the high-injury-risk age cohort (14-34 years) by 7.0 million (-8.2%). The reduction in the high-injury-risk age cohort should reduce the overall volume of penetrating and blunt injury nationally despite a population increase of 21 million. However, the number of, and the proportion of, elderly victims of(More)
The relationship between number of prescriptions per office visit and the appropriateness of the prescribed drugs is examined, using data on more than 20,000 prescriptions purchased for a low-income rural population during 1973 and 1974. Criteria for drug appropriateness are based on an AMA evaluation of drugs. The results show that greater numbers of(More)
The ability of adenosine to stimulate adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and increase adenosine 3':5'-cyclic monophosphate (cAMP) levels has important biochemical consequences. These include the suppression of immune responses and cardiovascular effects. Recent investigations involving the ability of adenosine and adenosine(More)
A focus on health care delivery systems and the emergence of New Health Practitioners, particularly Physicians' Assistants (PAs), represents one of the more significant nonbiomedical developments in American medicine since World War II. Much discussion about PAs revolves around the kinds of illnesses they are qualified to treat which then permits physicians(More)
The present study of general and romantic adult attachment among 484 female and male college students compared those who resided with an alcohol-abusing parent prior to age 16 and those who did not. Participants completed the Relationship Style Questionnaire (RSQ; general adult attachment), Experiences in Close Relationships-Revised (ECR-R; romantic(More)
The antiviral activity of ribavirin has been associated with its inhibition of the enzyme, IMP dehydrogenase. The ability of ribavirin to inhibit this enzyme has previously been shown to be related to its stability in the high anti glycosidic conformation. The antiviral effectiveness of several analogs of ribavirin have been investigated recently. The(More)
Ara-C at very low dosage has been reported to decrease the host toxicity of ara-AMP or ara-A in combination with 2'-deoxycoformycin, a potent adenosine deaminase inhibitor, while increasing the toxicity to intracerebral L1210 leukemia. The possibility of increasing the selectivity of ara-A by prior administration of ara-C is explored. The importance of(More)
The ability of polynucleotides or polynucleotide duplexes such as poly(I).poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1--3 kcal/mole (1 cal = 4.184 J) in the conformational regions near 20 degrees, 80 degrees, and 160 degrees(More)
For maximum effectiveness, the delivery of social services and mental health services in a rural area must accommodate certain constraints imposed by the structure of the community. Accommodation to the community can be achieved best when an established and accepted institution provides structure and legitimization for the social service and the mental(More)