Denise Collins

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In order to study the effect of decreasing plasma tryptophan levels on aggressive responding in a controlled laboratory setting, we administered two doses (25 g and 100 g) of a tryptophan-free amino acid mixture to ten healthy male subjects after 24 h of a low tryptophan diet. Subjects were screened for current or past psychiatric, or non-psychiatric(More)
Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study the initial effects of a cervical spine(More)
Although dysphagia is a common problem for many Parkinson's disease (PD) patients, the effect of deep brain stimulation (DBS) on swallowing is unclear. Fourteen subjects with advanced PD underwent videofluorographic swallowing studies prior to bilateral DBS of the subthalamic nucleus (STN) and at 3 and 12 months postprocedure. They were tested under several(More)
OBJECTIVE To determine the relationship between paracetamol administration and skin blood flow (skBF) and blood pressure (BP) in critically ill patients treated for fever. DESIGN Prospective, observational study. SETTING Intensive care units of university teaching hospital. PATIENTS 29 adults (17 males and 12 females), aged 58±15 years treated with(More)
syndromes with known serum antibodies, such as relapsing polychondritis and Sjögrens, have been subsequently diagnosed in patients presenting with subacute encephalopathy. The aetiology of a humourally mediated central nervous system condition may require initial compromise of the blood– brain barrier. This could expose the brain to serum factors, such as(More)
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