Denise Chapple

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Baclofen is a muscle relaxant used in both adults and children with neuromuscular disorders to control spasticity. In children, relatively few cases of overdose have been previously reported. We report two cases of baclofen overdose occurring in two siblings. One sibling with cerebral palsy was being treated with baclofen at the time of overdose. Both cases(More)
Intravenous dose-response relationships were used to correlate neuromuscular paralysis with effects on autonomic mechanisms in anaesthetized cats. Whereas autonomic blockade with tubocurarine occurred at parasympathetic and sympathetic ganglia, neuromuscular paralysing doses of gallamine, alcuronium, pancuronium and fazadinium caused blockade at vagal(More)
Intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. Sympathetic function was unimpaired by supramaximal paralysing(More)
OBJECTIVE The objective of this study was to evaluate the effect of the timing of surgical repair of nonductal dependent coarctation on the short-term outcome. METHODS The medical records of 76 patients, diagnosed and treated for a nonductal dependent mild-to-moderate coarctation at a tertiary care institute over a 20-year period, were retrospectively(More)
Atracurium, a new competitive neuromuscular blocking agent, is broken down in the body by two mechanisms, Hofmann elimination and ester hydrolysis. Chemical breakdown by Hofmann elimination is rapid at physiological pH and temperature, whereas ester hydrolysis is enzyme-catalysed but by enzymes other than pseudocholinesterase. The products of these(More)
The neuromuscular and cardiovascular effects of the breakdown products of atracurium and related substances have been studied in cats anaesthetized with chloralose. Laudanosine, the quaternary acid and metholaudanosine had no neuromuscular blocking activity within the dose range 0.5-4 mg kg-1. However, the quaternary monoacrylate, the quaternary alcohol and(More)
1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was determined indirectly at various times after its administration to eight conscious dogs by measurement of the intravenous dose of acetylstrophanthidin necessary to induce toxic changes in the ECG. Acetyl-strophanthidin was used because its rapid elimination from the body(More)
The effects of BW12C on myocardial function in the erythrocyte-perfused rabbit heart and on myocardial infarct size in the anaesthetized dog have been evaluated. Perfusion of rabbit hearts with erythrocytes pretreated with BW12C (10(-3) M-4 X 10(-3) M) produced concentration-dependent decreases in left ventricular pressure (LVP), LVP dP/dt and coronary(More)