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The G protein-coupled receptors of the C-X-C subfamily form a group among the chemokine receptors whose endogenous ligands are peptides with a common Cys-X-Cys motif. The CXC chemokine receptors 3… Continue Reading
Drug optimization is guided by biophysical methods with increasing popularity. In the context of lead structure modifications, the introduction of methyl groups is a simple but potentially powerful… Continue Reading
Modulating protein activity with small-molecules binding to cryptic pockets offers great opportunities to overcome hurdles in drug design. Cryptic sites are atypical binding sites in proteins that… Continue Reading
The present invention relates to a device for securing at least one of a loading area (L) of a vehicle mounted object (G1-G3), with at least one securing element (1) that is at least power-operated… Continue Reading