Denis N. Khatri

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OBJECTIVE To examine cardioprotective effects of Ρ-terminal fragment of adipokine apelin-12 (A12), its novel structural analogue [MeArg(1), NLe(10)]-A12 (I), and [d-Ala(12)]-A12 (II), a putative antagonist of APJ receptor, employing in vivo model of ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS Peptides were synthesized by the automatic solid(More)
65 INTRODUCTION The adipocytokine apelin peptide, which consists of 77 amino acid residues, and its APJJreceptor conn nected with GGproteins of membranes of endothelial cells and cardiomyocytes participate in regulation of the tone of coronary blood vessels and contractility of the myocardium [1]. CCterminal fragments of the pepp tide (apelinn12, 13, and(More)
Apelin-12 (A-12) peptide was synthesized by automated solid phase method and purified by reverse phase HPLC. Its homogeneity and structure were confirmed by HPLC, (1)H-NMR spectroscopy, and mass spectroscopy. Acute myocardial infarction was induced by 40-min occlusion of the left coronary artery with subsequent 60-min reperfusion in narcotized Wistar rats.(More)
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