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  • Jeff R McArthur, Gaurav Singh, Denis McMaster, Robert Winkfein, D. Peter Tieleman, Robert J French
  • Chemistry, Medicine
  • Molecular pharmacology
  • 2011 (First Published: 1 October 2011)
  • Voltage-gated sodium channels are important in initiating and propagating nerve impulses in various tissues, including cardiac muscle, skeletal muscle, the brain, and the peripheral nerves.Continue Reading
  • Matthew D. Fuller, Christopher H. Thompson, +10 authors Nael A. Mccarty
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 2007 (First Published: 28 December 2007)
  • Peptide toxins from animal venom have been used for many years for the identification and study of cation-permeable ion channels. However, no peptide toxins have been identified that interact withContinue Reading
  • Jeff R McArthur, Vitaly Ostroumov, Ahmed Al-Sabi, Denis McMaster, Robert J French
  • Chemistry, Medicine
  • Biochemistry
  • 2011 (First Published: 11 January 2011)
  • The first μ-conotoxin studied, μCTX GIIIA, preferentially blocked voltage-gated skeletal muscle sodium channels, Na(v)1.4, while μCTX PIIIA was the first to show significant blocking action againstContinue Reading
  • Jeffrey R McArthur, Gurpreet Singh, Denis McMaster, D. Peter Tieleman, Robert J French
  • Chemistry
  • 2011 (First Published: 1 February 2011)
  • μ-Conotoxins are highly basic peptides which block the ion conduction pathway of voltage-gated sodium (NaV) channels by a combination of steric and electrostatic actions. Toxins, which block NaVContinue Reading