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Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1).

• Denis Josse, Christine Ebel, +8 authors Patrick Masson
• The Journal of biological chemistry
• 2002

Human plasma paraoxonase (HuPON1) is a high density lipoprotein (HDL)-bound enzyme exhibiting antiatherogenic properties. The molecular basis for the binding specificity of HuPON1 to HDL has not been… (More)

New CeO2 nanoparticles-based topical formulations for the skin protection against organophosphates

• Arnaud Zenerino, Tifenn Boutard, +4 authors Frédéric Guittard
• Toxicology reports
• 2015

To reinforce skin protection against organophosphates (OPs), the development of new topical skin protectants (TSP) has received a great interest. Nanoparticles like cerium dioxide (CeO2) known to… (More)

Hair analysis as a useful procedure for detection of vapour exposure to chemical warfare agents: simulation of sulphur mustard with methyl salicylate.

• Marie Spiandore, Anne Piram, Alexandre Lacoste, Denis Josse, Pierre Doumenq
• Drug testing and analysis
• 2014

Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited… (More)

Efficacy of scalp hair decontamination following exposure to vapours of sulphur mustard simulants 2-chloroethyl ethyl sulphide and methyl salicylate.

• Marie Spiandore, Anne Piram, +6 authors Pierre Doumenq
• Chemico-biological interactions
• 2017

Chemical warfare agents are an actual threat and victims' decontamination is a main concern when mass exposure occurs. Skin decontamination with current protocols has been widely documented, as well… (More)

In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions--evidence for a wash-in effect.

• Jan Misík, Růžena Pavlíková, Denis Josse, Jiří Cabal, Kamil Kuca
• Toxicology mechanisms and methods
• 2012

Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of… (More)

Pickering emulsions for skin decontamination.

• Alicia Salerno, Marie-Alexandrine Bolzinger, Pauline Rolland, Yves Chevalier, Denis Josse, Stéphanie Briançon
• Toxicology in vitro : an international journal…
• 2016

This study aimed at developing innovative systems for skin decontamination. Pickering emulsions, i.e. solid-stabilized emulsions, containing silica (S-PE) or Fuller's earth (FE-PE) were formulated.… (More)

Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model.

• David T Yeung, Denis Josse, +5 authors Douglas M. Cerasoli
• Biochimica et biophysica acta
• 2004

Human serum paraoxonase (HuPON1) is a calcium-dependent enzyme that hydrolyzes esters, including organophosphates and lactones, and exhibits anti-atherogenic properties. A few amino acids have been… (More)

In vitro skin decontamination of the organophosphorus pesticide Paraoxon with nanometric cerium oxide CeO2.

• Alicia Salerno, Thierry Devers, Marie-Alexandrine Bolzinger, Jocelyne Pelletier, Denis Josse, Stéphanie Briançon
• Chemico-biological interactions
• 2017

Organophosphorus compounds (OP), which mainly penetrate via the percutaneous pathway, represent a threat for both military and civilians. Body surface decontamination is vital to prevent victims… (More)

Showering effectiveness for human hair decontamination of the nerve agent VX.

• Denis Josse, Julien Wartelle, C. M. Vera Cruz
• Chemico-biological interactions
• 2015

In this work, our goals were to establish whether hair decontamination by showering one hour post-exposure to the highly toxic organophosphate nerve agent VX was effective, whether it required the… (More)

Desorption of sulphur mustard simulants methyl salicylate and 2-chloroethyl ethyl sulphide from contaminated scalp hair after vapour exposure.

• Marie Spiandore, Mélanie Souilah-Edib, Anne Piram, Alexandre Lacoste, Denis Josse, Pierre Doumenq
• Chemosphere
• 2018

Chemical warfare agents have been used to incapacitate, injure or kill people, in a context of war or terrorist attack. It has previously been shown that hair could trap the sulphur mustard simulants… (More)

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