Denis E. O’Donnell

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Dyspnea, exercise intolerance, and activity restriction are already apparent in mild chronic obstructive pulmonary disease (COPD). However, patients may not seek medical help until their symptoms become troublesome and persistent and significant respiratory impairment is already present; as a consequence, further sustained physical inactivity may contribute(More)
BACKGROUND The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. AIM To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. METHODS 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered(More)
Dynamic lung hyperinflation as the common pathway for exercise-induced dyspnoea in cardio-respiratory diseases soutenue le 18 juin 2012 devant le jury composé de : Le support logistique a été fourni par l'ADOREPSACKNOWLEDGEMENTS First and foremost, I would like to thank my supervisor, Dr. Thomas Similowski, for his continued help, unwavering support, expert(More)
RATIONALE Exacerbations of COPD are defined clinically by worsening of chronic respiratory symptoms. Chronic respiratory symptoms are common in the general population. There are no data on the frequency of exacerbation-like events in individuals without spirometric evidence of COPD. AIMS To determine the occurrence of 'exacerbation-like' events in(More)
BACKGROUND We hypothesized that heterogeneity exists within the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 spirometric category and that different subgroups could be identified within this GOLD category. METHODS Pre-randomization study participants from two clinical trials were symptomatic/asymptomatic GOLD 1 chronic obstructive(More)
Background/Purpose: The 85+-year-old population – the " oldest old " – is now the fastest growing age segment in Canada. Although existing research demonstrates high health services utilization and prescribed medications in this population , little epidemiological evidence is available to guide care for this age group. Objective: To describe the(More)
BACKGROUND Thoracic computed tomography (CT) scans are widely performed in clinical practice, often leading to detection of airway or parenchymal abnormalities in asymptomatic or minimally symptomatic individuals. However, clinical relevance of CT abnormalities is uncertain in the general population. METHODS We evaluated data from 1361 participants aged(More)
BACKGROUND Long-term oxygen therapy (LTOT) is the only component of the management of chronic obstructive pulmonary disease (COPD) that improves survival in patients with severe daytime hypoxemia. LTOT is usually provided by a stationary oxygen concentrator and is recommended to be used for at least 15-18 h a day. Several studies have demonstrated a(More)
BACKGROUND To have a better understanding of the mechanisms of exercise limitation in mild-to-moderate chronic obstructive pulmonary disease (COPD), we compared detailed respiratory physiology in patients with COPD and healthy age- and sex-matched controls. METHODS Data were collected during the pre-treatment, patient characterization phase of a(More)