Denis C Guttridge

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BACKGROUND Tumor initiation has been attributed to haploinsufficiency at a single locus for a large number of cancers. Patched1 (Ptc1) was one of the first such loci, and Ptc1 haploinsufficiency has been asserted to lead to medulloblastoma and rhabdomyosarcoma in mice. PROCEDURE To study the role of Ptc1 in cerebellar tumor development and to create a(More)
INTRODUCTION The two hit hypothesis proposed that loss of both copies of a tumor suppressor gene could be required for tumor initiation [1]. However, in developmental biology [2] and cancer biology [3] haploinsufficiency has been recognized as a mechanism by which altered gene dosage can lead to stochastic imbalances in gene expression with phenotypic or(More)
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