Denis A. Fedorenko

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Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of systemic autoimmune diseases, but its consequences for the immune system remain poorly understood. Here, we describe an optimized RNA-based technology for unbiased amplification of T cell receptor beta-chain libraries and use it to perform the first detailed,(More)
High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. In this paper, we present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of HDIT + AHSCT with reduced-intensity(More)
High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (auto-HSCT) is a new and promising approach to the treatment of multiple sclerosis (MS) patients because currently there are no effective treatment methods for this disease. In this article, we present results of a prospective clinical study of efficacy of(More)
We studied the effect of light-induced gliding of the easy axis of dye-doped nematic liquid crystal on an aligning polymer surface. The observed drift of the easy axis is over tens of degrees and is caused by light-induced anisotropic adsorption and/or desorption of dye molecules on or from the aligning layer in the presence of light-induced bulk torque. We(More)
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (AHSCT) is a new and promising approach to multiple sclerosis (MS) treatment. In this article, we present the results of a prospective phase II open-label single-center study with the analysis of the safety and efficacy of high-dose immunosuppressive therapy+AHSCT(More)
During the last several years high-dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) has been established as a therapeutic option for multiple sclerosis (MS) patients. We report on the long-term effects of HDCT + ASCT in two female patients affected by secondary progressive and relapsing-remitting types of MS, respectively. As a(More)
Fast surface reorientation induced by a single 4-ns low-energy laser pulse in dye-doped liquid crystals is reported. The reorientation is due to light-induced modification of the surface anisotropy, which affects the liquid crystal's director through the appearance of a preferred direction on the irradiated surface. The detected signals can be interpreted(More)
We found the effect of a hidden photoalignment of a dye-doped nematic liquid crystal (LC) on a nonphotosensitive polymer surface after polarized irradiation of the cell in the isotropic phase. We observed that irradiation resulted in a uniform planar orientation of the LC after cooling to the mesophase. The direction of a light-induced easy axis on the(More)
A series of experiments was carried out to describe the evolution of light-induced anchoring in dye-doped nematic liquid crystals (LCs) at irradiation with polarized light. The experiments included cells filled with a pure pentyl-cyanobiphenyl (5CB) and containing a layer of azo dye deposited on an aligning film, as well as cells filled with azo dye doped(More)