Dengfeng Liu

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CONTEXT Neuroanatomic abnormalities in schizophrenia may underlie behavioral manifestations. Characterization of such abnormalities is required for interpreting functional data. Frontotemporal abnormalities have been documented by using predetermined region-of-interest approaches, but deformation-based morphometry permits examination of the entire brain. (More)
RATIONALE AND OBJECTIVES Brain lesions, especially white matter lesions (WMLs), are associated with cardiac and vascular disease, but also with normal aging. Quantitative analysis of WML in large clinical trials is becoming more and more important. MATERIALS AND METHODS In this article, we present a computer-assisted WML segmentation method, based on(More)
OBJECTIVE No clear consensus exists regarding the effect of sustained, heavy drinking on hippocampal volume. Our prior work hypothesized significantly lowered total hippocampus volumes in heavy chronically drinking alcohol-dependent (AD) subjects compared with light-drinking nondependent control subjects matched for age and gender. METHOD Using a series(More)
This paper studies brain morphometry variation associated with XXY males (Klinefelter's syndrome) by using an automated whole-brain volumetric analysis method. The application to 34 XXY males and 62 normal male controls reveals pronounced volume reduction in the brains of XXY males, relative to the brains of normal controls, localized at the insula,(More)
This paper presents a fully automatic white matter lesion (WML) segmentation method, based on local features determined by combining multiple MR acquisition protocols, including T1-weighted, T2-weighted, proton density (PD)-weighted and fluid attenuation inversion recovery (FLAIR) scans. Support vector machines (SVMs) are used to integrate features from(More)
An image analysis method was developed for spatial normalization of spine magnetic resonance images. A deformable shape model of the spine is first constructed, and it is subsequently used by an automated algorithm to find a shape transformation that places patient data into a stereotactic space. Very good agreement with manual segmentations was observed.(More)
PURPOSE MicroRNA-206 (miR-206) has been proven to be downregulated in many human malignancies and is correlated with tumor progression. However, the roles of miR-206 and its related molecular mechanisms in oral squamous cell carcinoma (OSCC) are still unclear. Thus, the aim of this study was to explore the effects of miR-206 in OSCC tumorigenesis and(More)
OBJECTIVE The effects of hypercortisolism on hippocampal volume have not been studied in heavy drinkers. Prior work suggested increased hypothalamic-pituitary-adrenal activity in relation to lowered total hippocampus volume (THV) in heavy-drinking alcohol-dependent (AD) subjects. The present study hypothesized the following: (1) that chronic heavy-drinking(More)
Water quality assessment entails essentially a multi-criteria decision-making process accounting for qualitative and quantitative uncertainties and their transformation. Considering uncertainties of randomness and fuzziness in water quality evaluation, a cloud model-based assessment approach is proposed. The cognitive cloud model, derived from information(More)