Learn More
CONTEXT Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity. OBJECTIVE To evaluate the association of pedometer use with physical activity and health outcomes among outpatient adults. DATA SOURCES English-language articles from MEDLINE, EMBASE, Sport Discus, PsychINFO,(More)
BACKGROUND Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mortality in key clinical subgroups are uncertain. We undertook a collaborative analysis of data from(More)
CONTEXT Low-carbohydrate diets have been popularized without detailed evidence of their efficacy or safety. The literature has no clear consensus as to what amount of carbohydrates per day constitutes a low-carbohydrate diet. OBJECTIVE To evaluate changes in weight, serum lipids, fasting serum glucose, and fasting serum insulin levels, and blood pressure(More)
BACKGROUND Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia, is increasingly used for off-label indications. PURPOSE To evaluate the benefits and harms of rFVIIa use for 5 off-label, in-hospital indications: intracranial hemorrhage, cardiac surgery, trauma, liver transplantation, and prostatectomy. DATA SOURCES Ten databases(More)
BACKGROUND The rates of induction of labor and elective induction of labor are increasing. Whether elective induction of labor improves outcomes or simply leads to greater complications and health care costs is commonly debated in the literature. PURPOSE To compare the benefits and harms of elective induction of labor and expectant management of(More)
BACKGROUND Given the threat of bioterrorism and the increasing availability of electronic data for surveillance, surveillance systems for the early detection of illnesses and syndromes potentially related to bioterrorism have proliferated. PURPOSE To critically evaluate the potential utility of existing surveillance systems for illnesses and syndromes(More)
BACKGROUND There is increased interest in quantitative ultrasound for osteoporosis screening because it predicts fracture risk, is portable, and is relatively inexpensive. However, there is no consensus regarding its accuracy for identifying patients with osteoporosis. PURPOSE To determine the sensitivity and specificity of calcaneal quantitative(More)
BACKGROUND The health benefits of organic foods are unclear. PURPOSE To review evidence comparing the health effects of organic and conventional foods. DATA SOURCES MEDLINE (January 1966 to May 2011), EMBASE, CAB Direct, Agricola, TOXNET, Cochrane Library (January 1966 to May 2009), and bibliographies of retrieved articles. STUDY SELECTION(More)
BACKGROUND Human growth hormone is reportedly used to enhance athletic performance, although its safety and efficacy for this purpose are poorly understood. PURPOSE To evaluate evidence about the effects of growth hormone on athletic performance in physically fit, young individuals. DATA SOURCES MEDLINE, EMBASE, SPORTDiscus, and Cochrane Collaboration(More)
During the 2001 US anthrax attacks, mortality from inhalational anthrax was significantly lower than had been reported historically, which was attributed in part to early identification and timely treatment. During future attacks, clinicians will rely on published descriptions of the clinical features of inhalational anthrax to rapidly diagnose patients and(More)