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Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer
Findings indicated that curcumin could inhibit HGF-promoted EMT and angiogenesis by targeting c-Met and blocking PI3K/Akt/mTOR pathways.
Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells
Findings indicated a novel pathway for curcumin regulation of ROS-lysosomal–mitochondrial pathway and provided the key mechanism of regulation of LMP in cell apoptosis, which may be exploited for cancer treatment.
Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasion
Curcumin (diferuloylmethane) has chemopreventive and therapeutic properties against many types of tumors, both in vitro and in vivo. Previous reports have shown that curcumin exhibits anti‐invasive…
MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met /PI3k/Akt/mTOR pathway
It is found that hepatocyte growth factor induces EMT, invasion and migration in A549 and 95D lung cancer cells, and miR-206 could be a potential target for the therapeutic strategy against EMT and angiogenesis of lung cancer.
Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway.
miR‐1‐3p and miR‐206 sensitizes HGF‐induced gefitinib‐resistant human lung cancer cells through inhibition of c‐Met signalling and EMT
- Demin Jiao, Jun Chen, Qingyong Chen
- Biology, ChemistryJournal of cellular and molecular medicine
- 17 April 2018
The study for the first time indicated the new function of miR‐1‐3p and miR-206 in overcoming HGF‐induced gefitinib resistance in EGFR mutant lung cancer cell.
Study on the mechanism of JAK2/STAT3 signaling pathway-mediated inflammatory reaction after cerebral ischemia
- Yu-quan Wu, Juan Xu, J. Xu, Wei Zheng, Qingyong Chen, Demin Jiao
- BiologyMolecular medicine reports
- 24 January 2018
Investigation of the mechanism by which the Janus kinase (JAK)2/signal transducer and activator of transcription (STAT)3 signaling pathway mediates cerebral ischemia and the efficacy of pharmaceutical intervention found inhibition of the JAK2/STAT3 signalling pathway, such as curcumin, can reduce the expression of HMGB1 in brain tissue after cerebral isChemia, which can significantly reduce the inflammatory response after cerebral waschemia.
Identification of microRNA-93 as a functional dysregulated miRNA in triple-negative breast cancer
Several distinct differentially expressed miRNAs are found in TNBC, as compared to non-triple-negative breast cancer, and miR-93 may be considered as a biomarker associated with the biological and clinical characteristics of human TNBC.
Lower Serum Levels of miR-29c-3p and miR-19b-3p as Biomarkers for Alzheimer's Disease.
Next-generation sequencing on RNA extracted from the serum samples of 20 AD patients and 20 controls yielded 72 miRNAs with significantly changed expression levels, suggesting that miR-29c-3p or miB-19b-3P may contribute to the cognitive function of Alzheimer's disease.
Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs.
- Qingyong Chen, Li-Qun Xu, Li‐jun Wu
- BiologyInternational journal of molecular medicine
- 1 November 2011
Results indicate that the overexpression of Rac1 is tightly associated with an aggressive phenotype of lung cancer cells, and it is proposed that Rac1 could be a potential molecular target of gene therapy by RNAi-targeting in lungcancer cells.