Demetri M. Kokkinakis

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/v-Nitroso-2,6-dimethylmorpholine (NNDM) is an indirect ni-trosamine carcinogen which induces ductal adenocarcinoma of the pancreas in the Syrian golden hamster. NNDM is oxidized by normal male hamster pancreas postmitochondrial superna-tants (S-9) in the presence of reduced nicotinamide adenine dinucleotide phosphate and oxygen to give three major identi(More)
Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastomas (Daoy and D-341) and a lung non-small-cell adenocarcinoma with metastatic potential (H-1623) were most(More)
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