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Classical nonparametric spectral analysis uses sliding windows to capture the dynamic nature of most real-world time series. This universally accepted approach fails to exploit the temporal continuity in the data and is not well-suited for signals with highly structured time-frequency representations. For a time series whose time-varying mean is the… (More)

Understanding how ensembles of neurons represent and transmit information in the patterns of their joint spiking activity is a fundamental question in computational neuroscience. At present, analyses of spiking activity from neuronal ensembles are limited because multivariate point process (MPP) models cannot represent simultaneous occurrences of spike… (More)

Ising models are routinely used to quantify the second order, functional structure of neural populations. With some recent exceptions, they generally do not include the influence of time varying stimulus drive. Yet if the dynamics of network function are to be understood, time varying stimuli must be taken into account. Inclusion of stimulus drive carries a… (More)

- Gabriela Czanner, Sridevi V Sarma, Demba Ba, Uri T Eden, Wei Wu, Emad Eskandar +4 others
- Proceedings of the National Academy of Sciences…
- 2015

The signal-to-noise ratio (SNR), a commonly used measure of fidelity in physical systems, is defined as the ratio of the squared amplitude or variance of a signal relative to the variance of the noise. This definition is not appropriate for neural systems in which spiking activity is more accurately represented as point processes. We show that the SNR… (More)

- Massachu, Hoda Eydgahi, Jul, K Sorger, Carlos Lopez, John Albeck +68 others
- 2013

Using models to simulate and analyze biological networks requires principled approaches to parameter estimation and model discrimination. We use Bayesian and Monte Carlo methods to recover the full probability distributions of free parameters (initial protein concentrations and rate constants) for mass action models of receptor-mediated cell death. The… (More)

- Alyson Fletcher, Youssef Mestari, Demba Ba, Julius Kusuma, Ruby Pai, Lav Varshney +2 others
- 2006

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