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- R. Brenner, Gloria Pérez, +6 authors R. W. Aldrich
- Nature
- 2000
Small arteries exhibit tone, a partially contracted state that is an important determinant of blood pressure. In arterial smooth muscle cells, intracellular calcium paradoxically controls both… (More)
- Joshua Jacob Zaritsky, Delrae M. Eckman, George C. Wellman, Michael Nelson, Thomas L Schwarz
- Circulation research
- 2000
The molecular bases of inwardly rectifying K(+) (Kir) currents and K(+)-induced dilations were examined in cerebral arteries of mice that lack the Kir2.1 and Kir2.2 genes. The complete absence of the… (More)
- Mark S Taylor, Adrian D. Bonev, +5 authors Mark T. Nelson
- Circulation research
- 2003
The endothelium is a critical regulator of vascular tone, and dysfunction of the endothelium contributes to numerous cardiovascular pathologies. Recent studies suggest that apamin-sensitive,… (More)
- Snehal Naik, Charlotte K. Billington, +6 authors Raymond B. Penn
- The Journal of biological chemistry
- 2005
Cysteinyl leukotrienes activate the cysteinyl leukotriene type 1 receptor (CysLT1R) to regulate numerous cell functions important in inflammatory processes and diseases such as asthma. Despite its… (More)
- Ian Buxton, Deanna Cheek, Delrae M. Eckman, Danielle Westfall, K. M. Sanders, Kathleen D. Keef
- Circulation research
- 1993
Analogues of L-arginine with modifications at the terminal guanidino nitrogen and/or the carboxyl terminus of the molecule have been widely used for their ability to inhibit the production of nitric… (More)
- Delrae M. Eckman, N. Hopkins, C Mcbride, Kathleen D. Keef
- British journal of pharmacology
- 1998
1. Acetylcholine (ACh) elicits an endothelium-dependent relaxation and hyperpolarization in the absence of nitric oxide (NO) and prostaglandin synthesis in the guinea-pig coronary artery (GPCA). This… (More)
- Gouri Shanker, Jimmy L. Kontos, Delrae M. Eckman, Deborah J Wesley-Farrington, David C. Sane
- Journal of Thrombosis and Thrombolysis
- 2006
P2Y12 is the major platelet receptor that mediates ADP-induced aggregation. P2Y12 is also expressed by vascular cells. The factors that regulate P2Y12 expression have not been determined. Since… (More)
- Laura V. Gonzalez Bosc, Michael K Wilkerson, Karen Bradley, Delrae M. Eckman, David C. Hill-Eubanks, Mark T. Nelson
- The Journal of biological chemistry
- 2004
The transcription factor NFAT (nuclear factor of activated T-cells) is implicated in cardiac hypertrophy and vasculogenesis. NFAT activation, reflecting dephosphorylation by the calcium-dependent… (More)
- Delrae M. Eckman, Jennifer Frankovich, Kathleen D. Keef
- British journal of pharmacology
- 1992
1. The contractile and electrical responses to acetylcholine (ACh) in isolated segments of guinea-pig and rabbit coronary arteries were compared to those of the putative adenosine 5'-triphosphate… (More)
- Kathleen D. Keef, John Pasco, Delrae M. Eckman
- The Journal of pharmacology and experimental…
- 1992
Purinergic relaxation and hyperpolarization was investigated in the isolated guinea pig coronary artery (GPCA) and compared to purinergic relaxation in the rabbit coronary artery (RCA). Vessels were… (More)