Delphine Y.H. Cao

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AIMS To characterise carbapenemase-producing Enterobacteriaceae (CRE) isolated in Singapore. METHODS Carbapenemase genes and their flanking regions were amplified and sequenced by PCR. Isolates were typed by pulsed-field gel electrophoresis and multi-locus sequence typing. Plasmids bearing carbapenemase genes were sized by S1 nuclease digestion, Southern(More)
An imipenem-resistant Escherichia coli strain was isolated from the urine of a local 72-year-old female Chinese patient in 2006. The carbapenem MICs by Etest (bioMérieux SA, Marcy l’Etoile, France) were ertapenem at 2 g/ l, meropenem at 4 g/ l, and imipenem at 32 g/ l. A modified Hodge test was weakly positive. The presence of a metallo-lactamase (MBL) was(More)
To the Editor: Nordmann et al. (1) raised concern over the global spread of carbapenemase-producing Enterobacteriaceae. In their article, they called attention to the oxacillinase-48 (OXA-48) type carbapenemases because bacteria that produce these enzymes do not have a distinctive antimicrobial drug susceptibility profi le, and there is less awareness of(More)
Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #10-01, Singapore 117549, Singapore; Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Moulmein Road, Communicable Diseases Centre, Singapore 308433, Singapore; School of Medicine, Medical & Biological Sciences,(More)
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