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Follicular lymphoma (FL) B cells contract tight connections with their microenvironment, which governs the pathogenesis and progression of the disease. Indeed, specific immune response gene signatures, obtained from whole biopsy samples, have been associated with patient survival. In this study, we performed gene expression profiling of purified B cell and(More)
The dosage of soluble programmed cell death ligand 1 (sPD-L1) protein in the blood of adults with cancer has never been performed in a prospective patient cohort. We evaluated the clinical impact of sPD-L1 level measured at the time of diagnosis for newly diagnosed diffuse large B-cell lymphoma (DLBCL). Soluble PD-L1 was measured in the plasma of 288(More)
Immune checkpoint regulators such as PD-L1 have become exciting new therapeutic targets leading to long lasting remissions in patients with advanced malignancies. However, in view of the remarkable costs and the toxicity profiles of these therapies, predictive biomarkers able to discriminate responders from non-responders are urgently needed. In the present(More)
Accumulating evidence indicates that infiltrating stromal cells contribute directly and indirectly to tumor growth in a wide range of cancers. In follicular lymphoma (FL), malignant B cells are found admixed with heterogeneous lymphoid-like stromal cells within invaded lymph nodes and BM. In addition, mesenchymal stromal cells (MSCs) support in vitro FL(More)
Mature B cell differentiation involves a well-established transcription factor cascade. However, the temporal dynamics of cell signaling pathways regulating transcription factor network and coordinating cell proliferation and differentiation remain poorly defined. To gain insight into the molecular processes and extrinsic cues required for B cell(More)
In most hospital medical units, multidisciplinary committees meet weekly to discuss their patients' cases. The medical experts base their decisions on three sources of information. First, they check if their patient complies with existing guidelines. Failing these, the medical experts will base their therapeutic decisions on the cases of similar patients(More)
BACKGROUND Lymphoma occurring in patients aged 90 or older is not uncommon, and its incidence is expected to increase over time. Management of these patients is difficult given their underlying fragility and the lack of information regarding this population. PATIENTS AND METHODS We retrospectively analyzed 234 patients diagnosed with lymphoma at the age(More)
Semantic interoperability, a prerequisite to eHealth projects, relies on sharing both information and knowledge models between information systems. Two of the standards of information models are HL7 v3 and the European norm, EN13606/OpenEHR. The paper compares both standards on a fragment of the prenatal medical record, the APGAR score. Two factors are(More)
The study compares the effectiveness of Bayesian networks versus Decision Trees for predicting access to renal transplant waiting list in a French healthcare network. The data set consisted in 809 patients starting renal replacement therapy. The data were randomly divided into a training set (90%) and a validation set (10%). Bayesian network and CART(More)