Delphine Fagegaltier

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RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5' and 3' untranslated regions, and alternative operon structures. Here, by applying deep RNA sequencing to both the long and short RNA fractions (<50 nucleotides) obtained from the(More)
It has been proposed that dosage compensation in Drosophila males occurs by binding of two core proteins, MSL-1 and MSL-2, to a set of 35-40 X chromosome "entry sites" that serve to nucleate mature complexes, termed compensasomes, which then spread to neighboring sequences to double expression of most X-linked genes. Here we show that any piece of the X(More)
G3: Genes|Genomes|Genetics has removed 10.1534/g3.114.012203 from early online publication. The early online version of the article was published in error and is instead published early online at GENETICS as 10.1534/genetics.114.169268 at http://www.genetics.org/content/early/2014/07/24/genetics.114.169268, and the version of record will be published in the(More)
Germline genes often become re-expressed in soma-derived human cancers as "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among CTAs. However, whether and how the piRNA pathway contributes to oncogenesis in human neoplasms remain poorly understood. We found that oncogenic Ras combined with loss of the Hippo tumor(More)
Piwi proteins and their associated small RNAs are essential for fertility in animals. In part, this is due to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and, as such, form a molecular code that discriminates transposons from endogenous genes.(More)
The use of time series profiling to identify groups of functionally related genes (synexpression groups) is a powerful approach for the discovery of gene function. Here we apply this strategy during Ras(V12) immortalization of Drosophila embryonic cells, a phenomenon not well characterized. Using high-resolution transcriptional time-series datasets, we(More)
U01HG004274 (S.H.), and U41HG004269 (L.S.). Awards to S.E.C. and G.H.K. were carried out at LBNL under contract no. DE-AC02-05CH11231. Additional support was provided by the NSF under grant 0937060 to the Computing Research Association for the CIFellows Project (S.R.) and under award no. 0905968 (J.E.), a Natural Sciences and Engineering Research Council of(More)
MiRNAs bear an increasing number of functions throughout development and in the aging adult. Here we address their role in establishing sexually dimorphic traits and sexual identity in male and female Drosophila. Our survey of miRNA populations in each sex identifies sets of miRNAs differentially expressed in male and female tissues across various stages of(More)
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