Deliang Li

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Breast carcinoma is the most common female cancer with considerable metastatic potential. Discovery of new therapeutic approaches for treatment of metastatic breast cancer is still needed. Here, we reported our finding with niclosamide, an FDA approved anthelmintic drug. The potency of niclosamide on breast cancer was assessed in vitro and in vivo. In this(More)
Antagonizing vascular endothelial growth factor receptor 2 (VEGFR2) to block angiogenesis has been applied toward cancer therapy for its role in promoting cancer growth and metastasis. However, most these clinical anticancer drugs have unexpected side effects. Development of novel VEGFR2 inhibitors with less toxicity remains an urgent need. In this study,(More)
To study the molecular mechanism of action of ligustrazine, a low-density oligonucleotide microarray for cardiovascular disease-related genes, was constructed, and the preparation and hybridization protocols were optimized. Under the optimized conditions, the molecular mechanism of action of ligustrazine was analyzed with human umbilical vein endothelial(More)
White and purple color morphs of Corbicula have been identified all over the world. Previous studies suggested that the distinct difference of inner shell color, especially for sympatric individuals, derived mainly from their different genetic constitutions, not just environmental conditions. Two color morphs of Corbicula sympatric in Datong Lake were(More)
OBJECTIVES The primary purpose of this meta-analysis was to determine whether statin usage could reduce the risk of glucocorticoid-related osteonecrosis in animal models. METHODS A systematic literature search up to May 2015 was carried out using the PubMed, Ovid, EBM reviews, ISI Web of Science, EBSCO, CBM, CNKI databases with the term and boolean(More)
In the title compound, C(14)H(11)BrN(4), the fused benzene and pyrimidine rings are nearly coplanar, making dihedral angles of 1.26 (14) and 3.53 (15)° in the two independent mol-ecules. In the crystal structure, π-π stacking inter-actions [centroid-centroid distances = 3.4736 (19) and 3.5416 (19) Å] and weak N-H⋯N and N-H⋯Br inter-actions contribute to the(More)
Energy efficiency has been a main concern in wireless sensor networks where Medium Access Control (MAC) protocol plays an important role. However, current MAC protocols designed for energy saving have seldom considered multiple applications coexisting in WSN with variation of traffic load dynamics and different QoS requirements. In this paper, we propose an(More)
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