Delia N Sang

Learn More
A new continuous retinoblastoma cell line (Rb 355-7) derived from a nonfamilial unilaterally-affected child was studied morphologically and with regard to HLA expression. The tumor was compared with two older and widely studied cell lines, the Y-79 and WERI-Rb1 strains. The Rb 355-7 line grew in tissue culture in clusters and chains. Its doubling time was(More)
BACKGROUND AND OBJECTIVE Vascular endothelial growth factor (VEGF)-A, both necessary and sufficient in promoting ocular neovascularization, is an attractive therapeutic target. Combining nonselective and selective VEGF blockade may provide clinical benefit with minimal risks in the treatment of neovascular age-related macular degeneration (AMD). PATIENTS(More)
The occurrence of retinoblastoma in an eye with persistent hyperplastic primary vitreous (PHPV) is reported. These are both rare lesions. The absence of previous reports of their association has led to the clinical impression that the occurrence of PHPV in a microphthalmic eye precludes the presence of retinoblastoma. The coexistence of these lesions in the(More)
The occurrence of vascular basophilia in ocular tumors has been a selective histologic feature of retinoblastomas. We recently observed a metastatic oat-cell carcinoma to the choroid which also demonstrated such a vascular hematoxyphilia. Histologic review of a variety of ocular and orbital metastatic carcinomas failed to yield a similar basophilic pattern.(More)