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Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions.

• Dejan Caglič, Jerica Rozman Pungerčar, Gunnar Pejler, Vito Turk, Boris Turk
• The Journal of biological chemistry
• 2007

Lysosomal cysteine cathepsin B participates in numerous diverse cellular processes. In acquiring its activity, the proregion, which blocks the substrate-binding site in the proenzyme, needs to be… (More)

Autocatalytic processing of procathepsin B is triggered by proenzyme activity.

• Jerica Rozman Pungerčar, Dejan Caglič, +7 authors Boris Turk
• The FEBS journal
• 2009

Cathepsin B (EC 3.4.22.1) and other cysteine proteases are synthesized as zymogens, which are processed to their mature forms autocatalytically or by other proteases. Autocatalytic processing was… (More)

Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation.

• Dora Cavallo-Medved, Deborah L Rudy, Galia Blum, Matthew S Bogyo, Dejan Caglič, Bonnie F Sloane
• Experimental cell research
• 2009

Localization of proteases to the surface of endothelial cells and remodeling of the extracellular matrix (ECM) are essential to endothelial cell tube formation and angiogenesis. Here, we partially… (More)

Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.

• Jelena Rajković, Marcin Poręba, +7 authors Boris Turk
• The Journal of biological chemistry
• 2015

The genome of the parasite Trypanosoma cruzi encodes two copies of autophagy-related cysteine proteases, Atg4.1 and Atg4.2. T. cruzi autophagin-2 (TcAtg4.2) carries the majority of proteolytic… (More)

Silver nanoparticles on titanate nanobelts via the self-assembly of weak polyelectrolytes: synthesis and photocatalytic properties.

• Ines Bračko, Boštjan Jančar, Manca Logar, Dejan Caglič, Danilo Suvorov
• Nanotechnology
• 2011

A weak-polyelectrolyte multilayer on a surface of titanate nanobelts (Ti-NBs) was utilized as a template for in situ Ag nanoparticle formation in the fabrication of Ag-loaded Ti-NBs nanocomposites.… (More)

Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery.

• Dejan Caglič, G. Kosec, Lea Bojic, Thomas Reinheckel, Vito Turk, Boris Turk
• Biological chemistry
• 2009

Validation of drug targets and subsequent preclinical studies are usually carried out on animal disease models, with mouse being the most commonly used. However, results from mouse models cannot… (More)

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.

• Dejan Caglič, Anja Globisch, +8 authors K Ulrich Wendt
• Bioorganic & medicinal chemistry
• 2011

Near-infrared fluorophore (NIRF)-labeled imaging probes are becoming increasingly important in bio-molecular imaging applications, that is, in animal models for tumor imaging or inflammation studies.… (More)

Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe.

• Maik Kindermann, Heidi Roschitzki-Voser, +7 authors K Ulrich Wendt
• Chemistry & biology
• 2010

The role of caspase-1 in inflammation has been studied intensely over recent years. However, the research of caspase-1 has remained difficult mainly due to the lack of sensitive and selective tools… (More)

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis.

• Urška Požgan, Dejan Caglič, Blaž Rozman, Hideaki Nagase, Vito Turk, Boris Turk
• Biological chemistry
• 2010

Cysteine cathepsins and matrix metalloproteases are considered to play important roles in the development of arthritic diseases. Their accumulation in synovial fluid of primarily rheumatoid arthritis… (More)

The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes.

• Dejan Caglič, Urska Repnik, +9 authors Boris Turk
• Biological chemistry
• 2013

Osteoarthritis and rheumatoid arthritis are destructive joint diseases that involve the loss of articular cartilage. Degradation of cartilage extracellular matrix is believed to occur due to… (More)

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