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- Jingsheng Tuo, Christine M Bojanowski, +9 authors C. M. Chan
- Investigative ophthalmology & visual science
- 2007
PURPOSE
Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also… (More)
- Christine M Bojanowski, Defen Shen, +5 authors Jingsheng Tuo
- Environmental and molecular mutagenesis
- 2006
Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness among the elderly in Western countries. Genetic factors, age, cigarette smoking, nutrition, and exposure… (More)
- Lai Wei, Baoying Liu, +23 authors Robert B. Nussenblatt
- Cell reports
- 2012
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations… (More)
- Xiaoyan Ding, Mrinali M Patel, +7 authors C. M. Chan
- Investigative ophthalmology & visual science
- 2009
PURPOSE
To investigate the role of HtrA2/Omi, a nuclear-encoded mitochondrial serine protease with a proapoptosis function, under H(2)O(2)-induced oxidative stress in human RPE, in the… (More)
- Ellen F. Foxman, Meifen Zhang, +5 authors Igal Gery
- Journal of immunology
- 2002
Ocular inflammation leads to vision loss through the destruction and scarring of delicate tissues along the visual axis. To identify inflammatory mediators involved in this process, we used real time… (More)
- Xiaoguang Cao, Defen Shen, +4 authors C. M. Chan
- Pathology international
- 2011
Macrophages can be polarized to exhibit either pro-inflammatory M1 or pro-angiogenic M2 phenotypes, but have high phenotypic plasticity. This pilot study investigated macrophage polarization in the… (More)
- Chi-chao Chan, Emily Y Chew, Defen Shen, Joseph Hackett, Zhengping Zhuang
- Molecular vision
- 2005
PURPOSE
To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease.
METHODS
We found that co-expression of Epo and EpoR may mediate… (More)
- Jingsheng Tuo, Baitang Ning, +9 authors C. M. Chan
- Proceedings of the National Academy of Sciences…
- 2006
This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP) and its disease association. We chose… (More)
- C. C. Chan, Alexander O. Vortmeyer, +6 authors Z. Zhuang
- Archives of ophthalmology
- 1999
OBJECTIVE
Retinal angioma frequently occurs in von Hippel-Lindau (VHL) disease. However, VHL gene alterations have not been documented in retinal angiomas.
METHODS
Using tissue microdissection and… (More)
- Chi-chao Chan, Robert J. Ross, +7 authors Jingsheng Tuo
- Ophthalmic research
- 2008
BACKGROUND/AIMS
Senescent Ccl2-/- mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with… (More)