Deepti Suri

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Chronic granulomatous disease (CGD) results from an inherited defect in the phagocytic cells of the immune system. It is a genetically heterogenous disease caused by defects in one of the five major subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. There is a paucity of data from India on CGD. We herein describe the(More)
We describe autopsy findings in a 5-month-old infant with disseminated tuberculosis and congenital cytomegalovirus disease. The infant manifested with tubercular meningitis complicating as ruptured mycotic right middle cerebral artery aneurysm. Infiltrative, proliferative, and necrotizing vascular pathologies have been described; however, the occurrence of(More)
To assess complement levels C1q, C2, C3 and C4 in children with pediatric-onset lupus during the quiescent stage of disease. Thirty-four consecutive children with pediatric-onset SLE (onset below 12 years), in the quiescent stage were enrolled for the study. Twenty-nine age and sex matched healthy children were also enrolled for the purpose of comparison.(More)
Leukocyte adhesion deficiency (LAD) is a primary immuno-deficiency caused by a defect in the adherence of neutrophils to the wall of blood vessels. This failure in adherence results in an inability of transmigration of neutrophils through the endo-thelium to the site of inflammation [1]. Patients with LAD are predisposed to severe and life-threatening(More)
Chronic granulomatous disease (CGD) is an inheritable and genetically heterogeneous disease resulting from mutations in different subcomponents of the NADPH oxidase system. Mutations in the NCF2 gene account for <5% of all cases of CGD. We analyzed the clinical and laboratory findings of CGD with mutations in the NCF2 gene from amongst our cohort of CGD(More)
To the editor, Children with X-linked agammaglobulinemia (XLA) have a profound defect in B-lymphocyte development due to a mutation in BTK gene located on X chromosome. This results in severe hypogammaglobulinemia and an absence of circulating B cells. These children also have small to absent tonsils, and no palpable lymph nodes despite recurrent infections(More)
Pyoderma gangrenosum (PG) is an uncommon noninfectious neutrophilic dermatosis characterized by recurrent, sterile, necrotic skin ulcers. It is commonly associated with underlying systemic disease like inflammatory bowel disease, rheumatoid arthritis and hematological malignancies. Pathogenesis of PG remains unclear though aberrant immune responses have(More)
Good's syndrome is an eponymous, acquired immunological disorder characterized by the association of immunodeficiency with thymoma. It was first described six decades ago in 1954. The pathogenesis of this enigmatic disorder is still not clear although mutations in the TACI and BAFF-R genes have recently been reported. A 53-year-old male presented at our(More)