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Lipoprotein LprI of Mycobacterium tuberculosis Acts as a Lysozyme Inhibitor*
TLDR
Expression of the lprI gene in Mycobacterium smegmatis protected its growth from lysozyme inhibition in vitro and enhanced its phagocytosis and survival during intracellular infection of peritoneal and monocyte-derived macrophages, known to secrete ly sozyme, and in the presence of exogenously added lyso enzymes in secondary cell lines where lyso enzyme levels are low. Expand
DPROT: prediction of disordered proteins using evolutionary information
TLDR
The development of a computational method for predicting disordered proteins using sequence and profile compositions as input features for the training of SVM models using evolutionary information hidden in the multiple sequence alignment profile is described. Expand
Truncated Hemoglobin, HbN, Is Post-translationally Modified in Mycobacterium tuberculosis and Modulates Host-Pathogen Interactions during Intracellular Infection*
TLDR
The involvement of HbN in modulating the host-pathogen interactions and immune system of the host apart from protecting the bacilli from nitrosative stress inside the activated macrophages, consequently driving cells toward increased infectivity and intracellular survival is suggested. Expand
Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis
TLDR
A novel role of the CD loop and Pre-A motif is unraveled in assisting the interactions of the HbN with the reductase and the electron cycling, which may be vital for its NO-scavenging function. Expand
Intermolecular interactions in staphylokinase–plasmin(ogen) bimolecular complex: Function of His43 and Tyr44
TLDR
Molecular modeling studies revealed the role of these residues in making cation–pi and pi–pi interactions with Trp215 of Pm and thus establishing the crucial intermolecular contacts within the active site cleft of the activator complex for the cofactor activity of SAK. Expand
Truncated hemoglobin, HbO, carries an autokinase activity and facilitates adaptation of Mycobacterium tuberculosis under hypoxia.
TLDR
This study demonstrates that the redox dependent autokinase activity regulates oligomeric state and membrane association of HbO that generates a reservoir of oxygen in the proximity of respiratory membranes to sustain viability of Mtb under hypoxia. Expand
Prediction of residue-residue contacts in CASP12 targets from its predicted tertiary structures
TLDR
Predicted tertiary structure of a protein can be used for predicting residue-residue contacts in protein with high accuracy and performs better than most of CASP12 methods in the categories of TBM and TBM/FM. Expand