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Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental stimuli,(More)
Sensorineural hearing loss during early childhood alters auditory cortical evoked potentials in humans and profoundly changes auditory processing in hearing-impaired animals. Multiple mechanisms underlie the early postnatal establishment of cortical circuits, but one important set of developmental mechanisms relies on the neuromodulator serotonin(More)
30 Sensorineural hearing loss during early childhood alters auditory cortical evoked 31 potentials in humans and profoundly changes auditory processing in hearing-impaired animals. 32 Multiple mechanisms underlie the early postnatal establishment of cortical circuits, but one 33 important set of developmental mechanisms relies on the neuromodulator(More)
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