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OBJECTIVES To analyze the status of oxidative stress in relation to the degree of prematurity and birthweight of neonates. MATERIALS AND METHODS Umbilical cord blood samples were obtained at the time of delivery. 8-Hydroxy-2-deoxy guanosine (8-OHdG) has been measured as oxidative DNA damage marker in preterm low-birthweight (LBW) newborns by competitive(More)
An outbreak of axillary lymphadenitis and abscesses after Bacillus Calmette-Guérin (BCG) vaccination (Pasteur Paris, Batch N5122) occurred in 139 Jamaican children between January and July, 1988. The overall rate of this complication was 0.95%. The attack rate was 1.92% among the 0- to 6-week age group and 0.6% in the 7- to 52-week age group. Of 139(More)
BACKGROUND & AIMS Pre-eclampsia is associated with oxidative stress in the maternal circulation. The aim of the study was to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation; deficient antioxidant activity and inadequate trace elements during oxidative damage in the umbilical cord blood of(More)
OBJECTIVE The objective of the study is to investigate the association between oxidative stress markers and enzymatic / non-enzymatic antioxidants (marker of the resistance in body to oxidative damage) in the cord blood of preterm low birth weight (LBW) neonates. METHODS Malondialdehyde (MDA), carbonyl proteins, total antioxidant capacity and Vitamin A, E(More)
Pre-eclampsia is a devastating multi system syndrome and a major cause of maternal, fetal, neonatal morbidity and mortality. Pre-eclampsia is associated with oxidative stress in the maternal circulation. To have an insight on the effect of pre-eclampsia/eclampsia on the neonates, the study was made to explore the oxidative status by quantification of(More)
The study was designed to evaluate the markers of oxidative damage and to establish their diagnostic utility in breast carcinoma patients. Levels of 8-hydroxy-2-deoxyguanosine (8-OH-dG), protein carbonyl (PC), and malondialdehyde (MDA) along with total antioxidant status (TAS) were measured in breast carcinoma patients and controls. Receiver operating(More)
NF-κB is recognized as a redox-sensitive transcription factor and has been implicated in cellular response to oxidative stress. The study was designed to correlate the changes in antioxidant status with the levels of nuclear factor-κB (NF-κB) p65 subunit DNA-binding activity in relation to lymph node involvement, tumor size, and staging in breast carcinoma(More)
BACKGROUND Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS. METHODS Markers of oxidative(More)
A randomized placebo-controlled prospective trial was conducted to evaluate the efficacy of erythromycin therapy in 69 patients affected with Bacillus Calmette-Guérin lymphadenitis. When patients who developed subsequent regional abscesses were excluded, erythromycin caused significantly earlier resolution of lymphadenitis (5.1 months vs. 5.7 months for(More)
Selenium is an essential trace element that is important in proper immune system functioning and in free radical control. Selenium protects against heart weakness and degeneration. It is crucial for optimal health and detoxification. Selenium is required for the production of thyroid hormones. The body only needs a small amount. Nevertheless, the sele-nium(More)