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MOTIVATION Repetitive DNA sequences, besides having a variety of regulatory functions, are one of the principal causes of genomic instability. Understanding their origin and evolution is of fundamental importance for genome studies. The identification of repeats and their units helps in deducing the intra-genomic dynamics as an important feature of(More)
DevR regulon function is believed to be crucial for the survival of Mycobacterium tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the DevR regulon. All the regulon promoters were assigned to four classes based on the number of DevR binding sites (Dev boxes). A minimum of two boxes are essential for complete interaction(More)
— Most real-world search and optimization problems involve multiple conflicting objectives and results in a Pareto-optimal set. Various multi-objective optimization algorithms have been proposed for solving such problems with the goals of finding as many trade-off solutions as possible and maintaining diversity among them. Since last decade, Evolutionary(More)
— Despite the existence of a number of procedures for multi-objective optimization using evolutionary algorithms, there is still the need for a systematic and unbiased comparison of different approaches on a carefully chosen set of test problems. In this paper, a hybrid approach using PCX based NSGA-II and Sequential Quadratic Programming (SQP) is applied(More)
DevR is a transcriptional regulator that mediates the genetic response of Mycobacterium tuberculosis to oxygen limitation and nitric oxide exposure. devR is co-transcribed along with devS, which encodes its cognate sensor kinase, and an upstream gene, Rv3134c. The transcriptional activity of this operon was characterized by primer extension, transcriptional(More)
Path generation compliant mechanisms (PGCM) are flexible structures which generate some desired path and/or transmit force by undergoing elastic deformation (under some applied load) instead of through rigid linkages/joints as in rigid body mechanism. In the present work, multi-objective problem is posed for evolving of PGCM using local-search based genetic(More)
— A new bi-objective optimization problem is formulated for generating the diverse topologies of compliant mechanisms tracing a user-defined path. Motivation behind the present study is to generate the compliant mechanisms which perform the same task of tracing a prescribed trajectory near minimum-weight solution. Therefore, the constraint are imposed at(More)
— This paper presents a multi-objective evolutionary algorithm to solve the day-ahead thermal generation scheduling problem. The objective functions considered to model the scheduling problem are: 1) minimizing the system operation cost and 2) minimizing the emission cost. In the proposed algorithm, the chromosome is formulated as a binary unit commitment(More)
— In this paper, an improved initial random population strategy using a binary (0-1) representation of continuum structures is developed for evolving the topologies of path generating complaint mechanism. It helps the evolutionary optimization procedure to start with the structures which are free from impracticalities such as 'checker-board' pattern and(More)