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MOTIVATION Repetitive DNA sequences, besides having a variety of regulatory functions, are one of the principal causes of genomic instability. Understanding their origin and evolution is of fundamental importance for genome studies. The identification of repeats and their units helps in deducing the intra-genomic dynamics as an important feature of(More)
— Despite the existence of a number of procedures for multi-objective optimization using evolutionary algorithms, there is still the need for a systematic and unbiased comparison of different approaches on a carefully chosen set of test problems. In this paper, a hybrid approach using PCX based NSGA-II and Sequential Quadratic Programming (SQP) is applied(More)
DevR regulon function is believed to be crucial for the survival of Mycobacterium tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the DevR regulon. All the regulon promoters were assigned to four classes based on the number of DevR binding sites (Dev boxes). A minimum of two boxes are essential for complete interaction(More)
AIM To investigate whether the use of an oxidizing mouth rinse as an adjunct to chlorhexidine is efficacious in reducing stains and plaque. MATERIALS AND METHODS This study had a single-blind, three-group (n = 35 each) parallel design, including a 21 days experimental period during which group I rinsed with chlorhexidine (CHX) 0.2% alone, group II used(More)
— Most real-world search and optimization problems involve multiple conflicting objectives and results in a Pareto-optimal set. Various multi-objective optimization algorithms have been proposed for solving such problems with the goals of finding as many trade-off solutions as possible and maintaining diversity among them. Since last decade, Evolutionary(More)
DevR is a transcriptional regulator that mediates the genetic response of Mycobacterium tuberculosis to oxygen limitation and nitric oxide exposure. devR is co-transcribed along with devS, which encodes its cognate sensor kinase, and an upstream gene, Rv3134c. The transcriptional activity of this operon was characterized by primer extension, transcriptional(More)
Path generation compliant mechanisms (PGCM) are flexible structures which generate some desired path and/or transmit force by undergoing elastic deformation (under some applied load) instead of through rigid linkages/joints as in rigid body mechanism. In the present work, multi-objective problem is posed for evolving of PGCM using local-search based genetic(More)
— A new bi-objective optimization problem is formulated for generating the diverse topologies of compliant mechanisms tracing a user-defined path. Motivation behind the present study is to generate the compliant mechanisms which perform the same task of tracing a prescribed trajectory near minimum-weight solution. Therefore, the constraint are imposed at(More)
  • Rahul Checker, Santosh K. Sandur, Deepak Sharma, Raghavendra S. Patwardhan, S. Jayakumar, Vineet Kohli +3 others
  • 2012
BACKGROUND Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries, peppermint, rosemary, oregano and prunes and has been reported to possess antioxidant and anti-tumor properties. These properties of UA have been attributed to its ability to suppress NF-κB (nuclear factor(More)